Titanium and bioactive glass-ceramic coated titanium as materials for keratoprosthesis

Experimental Eye Research
R J LinnolaL Laatikainen

Abstract

The current problem with keratoprosthesis is the ingrowth of corneal or conjunctival epithelium into the anterior chamber. This may lead to infections and extrusion of the prosthesis as well as to the development of retroprosthetic membrane and secondary glaucoma. Glass-ceramic coated and uncoated titanium has been tested as material for the keratoprosthesis to prevent epithelial ingrowth. Twenty-two Supra-Descemet's membrane keratoprostheses were inserted in the eyes of 22 rabbits for 1, 2, 4, 8, or 12 months. The prosthesis had an optic part made of polymethylmetacrylate (PMMA). The support for the optic part and the flange of the prosthesis were made of titanium. Eleven of the prostheses were coated with glass-ceramic. The histological sections of the enucleated eyes were prepared through the central part of the cornea and the prosthesis using a cutting-grinding method. The histological analysis was made on both halves of the implants separately giving two analysis areas in each eye. All 11 titanium prostheses were retained for the time period planned. Two glass-ceramic coated prostheses were lost at 2 and 4 weeks, respectively. This was caused by difficulties at surgery due to a thick coating. These eyes were excluded from ...Continue Reading

Citations

Nov 24, 1999·Journal of Cataract and Refractive Surgery·R J LinnolaR P Happonen
Feb 11, 1998·Journal of Cataract and Refractive Surgery·R J Linnola
Jun 10, 2014·Journal of Biomedical Materials Research. Part a·Francesco Baino
Apr 27, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Amit TodaniClaes H Dohlman
Feb 7, 2013·Journal of Materials Science. Materials in Medicine·Reeta HuhtinenAndrew Lloyd

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