Titanium implants and silent inflammation in jawbone-a critical interplay of dissolved titanium particles and cytokines TNF-α and RANTES/CCL5 on overall health?

The EPMA Journal
J LechnerVolker von Baehr

Abstract

It is a well-known fact that titanium particles deriving from dental titanium implants (DTI) dissolve into the surrounding bone. Although titanium (TI) is regarded as a compatible implant material, increasing concern is coming up that the dissolved titanium particles induce inflammatory reactions around the implant. Specifically, the inflammatory cytokine tumor necrosis factor-alpha (TNF-α) is expressed in the adjacent bone. The transition from TNF-α-induced local inflammation following insertion of DTI surgery to a chronic stage of "silent inflammation" could be a neglected cause of unexplained medical conditions. The signaling pathways involved in the induction of cytokine release were analyzed by multiplex analysis. We examined samples of jawbone (JB) for seven cytokines in two groups: specimens from 14 patients were analyzed in areas of DTI for particle-mediated release of cytokines. Each of the adjacent to DTI tissue samples showed clinically fatty degenerated and osteonecrotic medullary changes in the JB (FDOJ). Specimens from 19 patients were of healthy JB. In five cases, we measured the concentration of dissolved Ti particles by spectrometry. All DTI-FDOJ samples showed RANTES/CCL5 (R/C) as the only extremely overexpres...Continue Reading

References

May 28, 1992·The New England Journal of Medicine·H J Mankin
Nov 1, 1973·Journal of Biomedical Materials Research·G Meachim, D F Williams
Dec 1, 1994·International Journal of Oral and Maxillofacial Surgery·D WeingartJ Simpson
Jan 1, 1996·Cytokine·I von LuettichauA M Krensky
Oct 3, 1998·Clinical Immunology and Immunopathology·M V VolinA E Koch
Apr 13, 2000·The Journal of Bone and Joint Surgery. American Volume·R M UrbanM Peoc'h
Mar 19, 2002·Zeitschrift für Orthopädie und ihre Grenzgebiete·A WilkeU Herz
Mar 29, 2002·American Journal of Respiratory Cell and Molecular Biology·Alaina J AmmitReynold A Panettieri
Apr 23, 2003·Implant Dentistry·Daniel OlmedoRómulo Luis Cabrini
May 19, 2005·Cranio : the Journal of Craniomandibular Practice·Jacques Imbeau
Apr 6, 2006·Clinical Oral Implants Research·Ulrich MeyerHans Peter Wiesmann
Aug 16, 2006·Clinical Oral Implants Research·Marja L LaineStefan Renvert
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Thomas DörnerAbdulgabar Salama
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Nov 7, 2006·Micron : the International Research and Review Journal for Microscopy·M FranchiA Ruggeri
Aug 10, 2007·Journal of Biomedical Materials Research. Part a·Daniel G OlmedoRómulo L Cabrini
Oct 29, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T SkurkC Herder
Dec 4, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J Ye
Apr 2, 2009·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·T P Chaturvedi
Jan 5, 2011·Frontiers in Bioscience (Elite Edition)·Iwona WertelJan Kotarski
Oct 25, 2011·Current Opinion in Pharmacology·Norikazu KiguchiShiroh Kishioka
Aug 29, 2012·International Journal of Oral and Maxillofacial Surgery·E Jacobi-GresserS Schütt
May 3, 2013·International Journal of General Medicine·Johann Lechner, Volker von Baehr
Aug 30, 2014·Clinical, Cosmetic and Investigational Dentistry·Johann Lechner
Nov 2, 2016·The EPMA Journal·Olga GolubnitschajaVincenzo Costigliola

❮ Previous
Next ❯

Citations

Aug 3, 2019·Clinical Implant Dentistry and Related Research·Yulan WangYufeng Zhang
Feb 6, 2019·Journal of Clinical Medicine·Adrien NaveauSreenivas Koka
Dec 31, 2020·BioMed Research International·Milad BaseriHossein Samadi Kafil
Apr 25, 2021·Oral Diseases·Caroline SekundoOliver Ristow
May 28, 2021·Journal of Oral Science·Taichi IshikawaHisatomo Kondo
Nov 3, 2021·Journal of Periodontology·Rita Del PintoDavide Pietropaoli
Jul 21, 2021··Ishak IbrahimRuslizam Daud

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

Perala
SPSS
xPonent®

Related Concepts

Related Feeds

Advanced Imaging of Cellular Signaling

Cell signaling is a vital mechanism for communication within cells and outside with the environment. Several different signaling pathways have been found and advanced imaging techniques are being developed to visualize the molecules involved in these signaling pathways. Find the latest research in advanced imaging of cellular signaling here.