Titanium surface bio-functionalization using osteogenic peptides: Surface chemistry, biocompatibility, corrosion and tribocorrosion aspects

Journal of the Mechanical Behavior of Biomedical Materials
Luciana D TrinoAnne George

Abstract

Titanium (Ti) is widely used in biomedical devices due to its recognized biocompatibility. However, implant failures and subsequent clinical side effects are still recurrent. In this context, improvements can be achieved by designing biomaterials where the bulk and the surface of Ti are independently tailored. The conjugation of biomolecules onto the Ti surface can improve its bioactivity, thus accelerating the osteointegration process. Ti was modified with TiO2, two different spacers, 3-(4-aminophenyl) propionic acid (APPA) or 3-mercaptopropionic acid (MPA) and dentin matrix protein 1 (DMP1) peptides. X-ray photoelectron spectroscopy analysis revealed the presence of carbon and nitrogen for all samples, indicating a success in the functionalization process. Furthermore, DMP1 peptides showed an improved coverage area for the samples with APPA and MPA spacers. Biological tests indicated that the peptides could modulate cell affinity, proliferation, and differentiation. Enhanced results were observed in the presence of MPA. Moreover, the immobilization of DMP1 peptides through the spacers led to the formation of calcium phosphate minerals with a Ca/P ratio near to that of hydroxyapatite. Corrosion and tribocorrosion results indic...Continue Reading

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Citations

Nov 8, 2020·Journal of Materials Science. Materials in Medicine·Carolina Simão AlbanoPaulo Noronha Lisboa-Filho
Jul 28, 2020·Heliyon·Carolina Simão AlbanoPaulo Noronha Lisboa-Filho
Jun 26, 2021·Frontiers in Molecular Biosciences·Laila A Damiati, Sarah El-Messeiry
Dec 24, 2021·Journal of Materials Science. Materials in Medicine·Shan LiWenjun Wang

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