PMID: 9429099Jan 16, 1998Paper

Titanium surface roughness alters responsiveness of MG63 osteoblast-like cells to 1 alpha,25-(OH)2D3

Journal of Biomedical Materials Research
B D BoyanZ Schwartz

Abstract

Surface roughness has been shown to affect differentiation and local factor production of MG63 osteoblast-like cells. This study examined whether surface roughness alters cellular response to circulating hormones such as 1 alpha,25-(OH)2D3. Unalloyed titanium (Ti) disks were pretreated with HF/HNO3 (PT) and then were machined and acid-etched (MA). Ti disks also were sandblasted (SB), sandblasted and acid etched (CA), or plasma sprayed with Ti particles (PS). The surfaces, from smoothest to roughest, were: PT, MA, CA, SB, and PS. MG63 cells were cultured to confluence on standard tissue culture polystyrene (plastic) or the Ti surfaces and then treated for 24 h with either 10(-8) M or 10(-7) M 1 alpha,25-(OH)2D3 or vehicle (control). Cellular response was measured by assaying cell number, cell layer alkaline phosphatase specific-activity, and the production of osteocalcin, latent (L) TGF beta, and PGE2. Alkaline phosphatase activity was affected by surface roughness; as the surface became rougher, the cells showed a significant increase in alkaline phosphatase activity. Addition of 1 alpha,25-(OH)2D3 to the cultures caused a dose-dependent stimulation of alkaline phosphatase activity that was synergistic with the effect caused by...Continue Reading

References

Jul 1, 1989·Physiological Reviews·P V HauschkaC M Gundberg
Dec 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L V HaleR E Wuthier
Oct 1, 1985·Journal of Biomedical Materials Research·K A Thomas, S D Cook
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J HambletonB D Boyan
Nov 1, 1994·Journal of Cellular Biochemistry·Z Schwartz, B D Boyan
Sep 1, 1996·Journal of Biomedical Materials Research·K KieswetterB D Boyan

❮ Previous
Next ❯

Citations

Nov 15, 2000·Journal of Biomedical Materials Research·B O AronssonP Descouts
Mar 20, 2001·Journal of Biomedical Materials Research·B D BoyanZ Schwartz
May 8, 2001·Journal of Biomedical Materials Research·A ItäläM Hupa
Feb 9, 2002·Journal of Biomedical Materials Research·S R BannisterZ Schwartz
Sep 5, 2002·Journal of Biomedical Materials Research·C H LohmannZ Schwartz
Nov 13, 2004·Journal of Biomedical Materials Research. Part a·Beatrice SommerWilly Hofstetter
Jun 22, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B D BoyanZ Schwartz
May 7, 2002·Cell Biology International·B A A SchevenR M Aspden
Dec 8, 2004·Mund-, Kiefer- und Gesichtschirurgie : MKG·T FilliesU Meyer
Aug 19, 2007·Journal of Materials Science. Materials in Medicine·Stefan EndresAxel Wilke
Aug 19, 2007·Journal of Materials Science. Materials in Medicine·Stefan EndresAxel Wilke
Jul 14, 2009·Journal of Materials Science. Materials in Medicine·Jae-Young JungWoo-Kul Lee
Oct 24, 2009·Journal of Materials Science. Materials in Medicine·D ScharnweberH Worch
Apr 30, 2013·Journal of Materials Science. Materials in Medicine·M Herrero-ClimentF J Gil
Mar 17, 2005·Biomaterials·Veronica BorsariRoberto Giardino
Feb 24, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Zvi SchwartzBarbara D Boyan
Jul 9, 2002·Biomaterials·Anita KapanenJuha Tuukkanen
May 3, 2003·Biomaterials·Rajiv K SethiArun S Shanbhag
Mar 11, 2000·Biomaterials·K Anselme
Jul 17, 2012·Photomedicine and Laser Surgery·Nai-Chia TengHaw-Ming Huang
Mar 13, 2008·Tissue Engineering. Part a·Jarema S CzarneckiPanagiotis A Tsonis
Sep 12, 2008·Implant Dentistry·Stefano TetèEnrico Gherlone
Jul 2, 2010·Journal of the Royal Society, Interface·Anders PalmquistPeter Thomsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.