Titanium surfaces with adherent selenium nanoclusters as a novel anticancer orthopedic material

Journal of Biomedical Materials Research. Part a
Phong TranThomas J Webster

Abstract

Current orthopedic implants have several problems that include poor osseointegration for extended periods of time, stress shielding and wear debris-associated bone cell death. In addition, numerous patients receive orthopedic implants as a result of bone cancer resection, yet current orthopedic materials were not designed to prevent either the occurrence or reoccurrence of cancer. The objective of this in vitro study was to create a new biomaterial which can both restore bone and prevent cancer growth at the implant-tissue interface. Elemental selenium was chosen as the biologically active agent in this study because of its known chemopreventive and chemotherapeutic properties. It was found that when selenite salts were reduced by glutathione in the presence of an immersed titanium substrate, elemental selenium nucleated and grew into adherent, hemispherical nanoclusters that formed a nanostructured composite surface. Three types of surfaces with different selenium surface densities on titanium were fabricated and confirmed by SEM images, AFM, and XPS profiles. Compared to conventional untreated titanium, a high-density selenium-doped surface inhibited cancerous bone cell proliferation while promoting healthy bone cell function...Continue Reading

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Citations

Jun 3, 2010·International Journal of Nanomedicine·Phong A TranThomas J Webster
May 28, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Joanna KolmasGrzegorz Nałęcz-Jawecki
Sep 13, 2012·Journal of Biomedical Materials Research. Part a·C Rodríguez-ValenciaP González
May 14, 2014·Advanced Drug Delivery Reviews·Alejandro Sosnik, Angel M Carcaboso
May 9, 2018·Biomedizinische Technik. Biomedical Engineering·Bunyamin AksakalZeynep A Sinirlioglu
Sep 23, 2018·Biointerphases·Victoria le Ching TanKate Fox
Nov 17, 2019·International Journal of Molecular Sciences·Kok-Lun Pang, Kok-Yong Chin

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