Titin transcripts in thymomas

Journal of Autoimmunity
G O SkeieN E Gilhus

Abstract

More than 90% of myasthenia gravis (MG) patients with a thymoma have antibodies against titin. We have identified titin mRNA transcripts in thymomas by RT-PCR and Southern blotting. The transcripts cover the main immunogenic region (MIR) and a central I-band epitope reactive with some MG patients' antibodies. The presence of the central I-band epitope was confirmed by immunohistochemistry as a titin antibody reactive with this part of titin, stained thymoma epithelial cells and a thymoma extract in Western blots. Our findings suggest that the initiation of paraneoplastic titin reactivity is correlated with the expression of titin sequences within the thymoma.

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Citations

Jan 13, 2005·Acta Neurologica Scandinavica·F RomiJ A Aarli
Nov 1, 2003·Annals of the New York Academy of Sciences·H ShionoN Willcox
Mar 1, 2006·Muscle & Nerve·Irit AvniAron S Buchman
Jul 21, 1998·Annals of the New York Academy of Sciences·J A AarliN E Gilhus
Apr 13, 2010·Autoimmunity·Kathleen VrolixPilar Martínez-Martínez
Apr 13, 2010·Autoimmunity·A MarxP Ströbel
Aug 14, 2012·Expert Review of Clinical Immunology·Matthew N Meriggioli, Donald B Sanders

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