PMID: 11902650Mar 21, 2002Paper

Titrimetric and spectrophotometric assay of some antihistamines through the determination of the chloride of their hydrochlorides

Il Farmaco
Kanakapura Basavaiah, V S Charan

Abstract

Two simple, rapid and reliable methods for the determination of four antihistamines based on the measurement of the chloride of their hydrochlorides are described. In the titrimetric method, the chloride content of each drug is determined by titrating with mercury(II) nitrate using diphenylcarbazone-bromothymol blue as indicator. In the spectrophotometric method, to a fixed concentration of mercury(II)-diphenylcarbazone complex different amounts of drug are added and the decrease in absorbance of mercury(II)-diphenylcarbazone complex, consequent to the replacement of diphenylcarbazone of the complex by the chloride of the drug, was measured at 540 nm. The stoichiometry of the reaction that forms the basis for titrimetry is assessed. Different variables affecting the color formation in spectrophotometry were studied and optimized. At the wavelength of maximum absorption, Beer's law is obeyed in the 0-100 microg ml(-1) range. The molar absorptivity and Sandell sensitivity are calculated. The proposed methods were applied for the analysis of pharmaceutical formulations containing these drugs. Statistical treatment of the experimental results indicates that the procedures are precise and accurate. Excipients used as additives in ph...Continue Reading

References

Feb 1, 1971·Journal of Pharmaceutical Sciences·F Matsui, W N French
Jul 10, 1998·Journal of Pharmaceutical and Biomedical Analysis·A F el WalilyM F Bedair
Jul 14, 2001·Journal of Pharmaceutical and Biomedical Analysis·M BenamorM T Draa
Nov 1, 1962·The Journal of Pharmacy and Pharmacology·H ABDINE, W S ABDEL SAYED

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Citations

Jun 3, 2004·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Isabel Pascual RegueraAntonio Molina Díaz
May 4, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Balasekhara R ChallaRihana P Shaik
Apr 20, 2007·Biomedical Chromatography : BMC·Piotr Kowalski, Alina Plenis
Sep 27, 2014·Marine Drugs·Ramiro J ZepedaHugo F Miranda

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