Tityus serrulatus venom peptidomics: assessing venom peptide diversity

Toxicon : Official Journal of the International Society on Toxinology
Breno RatesAdriano M C Pimenta

Abstract

MALDI-TOF-TOF and de novo sequencing were employed to assess the Tityus serrulatus venom peptide diversity. Previous works has shown the cornucopia of molecular masses, ranging from 800 to 3000Da, present in the venom from this and other scorpions species. This work reports the identification/sequencing of several of these peptides. The majority of the peptides found were fragments of larger venom toxins. For instance, 28 peptides could be identified as fragments from Pape proteins, 10 peptides corresponded to N-terminal fragments of the TsK beta (scorpine-like) toxin and fragments of potassium channel toxins (other than the k-beta) were sequenced as well. N-terminal fragments from the T. serrulatus hypotensins-I and II and a novel hypotensin-like peptide could also be found. This work also reports the sequencing of novel peptides without sequence similarities to other known molecules.

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Citations

Feb 13, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Pedro Po PardalHipócrates M Chalkidis
May 2, 2014·Journal of Proteomics·Xiaobo XuWenxin Li
Jan 3, 2015·Toxicon : Official Journal of the International Society on Toxinology·Ursula Castro de OliveiraInácio de Loiola Meirelles Junqueira-de-Azevedo
Nov 26, 2009·Toxicon : Official Journal of the International Society on Toxinology·Ricardo C Rodríguez de la VegaLourival D Possani
Dec 3, 2015·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Priscila C LimaEliane C Arantes
Jul 16, 2013·Toxicon : Official Journal of the International Society on Toxinology·Fagner Neves OliveiraElisabeth F Schwartz
Aug 6, 2014·Toxicon : Official Journal of the International Society on Toxinology·A O CarmoE Kalapothakis
Mar 19, 2013·Toxicon : Official Journal of the International Society on Toxinology·Marie-France Martin-EauclairePierre E Bougis
Sep 4, 2013·Toxicon : Official Journal of the International Society on Toxinology·Mohamed A Abdel-RahmanLourival D Possani
Feb 20, 2014·PLoS Neglected Tropical Diseases·Carolina Campolina Rebello HortaEvanguedes Kalapothakis
Jun 29, 2016·Toxicon : Official Journal of the International Society on Toxinology·Marie-France Martin-EauclaireMaria-Elena De Lima
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Oct 5, 2019·Toxicon : Official Journal of the International Society on Toxinology·Cecilia DíazMahmood Sasa
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Nov 13, 2018·Toxicon : Official Journal of the International Society on Toxinology·Valquíria Abrão Coronado DorceIvo Lebrun

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