TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Madhumita JagannathanBarbara S Nikolajczyk

Abstract

Chronic systemic inflammation links periodontal disease and diabetes to increased incidence of serious comorbidities. Activation of TLRs, particularly TLR2 and TLR4, promotes chronic systemic inflammation. Human B cells have been generally thought to lack these TLRs. However, recent work showed that an increased percentage of circulating B cells from inflammatory disease patients express TLR2 and TLR4, and that TLR engagement on B cells resulted in unexpected changes in gene expression. New data show that B cells from inflammatory disease patients secrete multiple cytokines in response to different classes of TLR ligands. Furthermore, the B cell response to combinations of TLR ligands is cytokine- and ligand-specific. Some cytokines (IL-1beta and IL-10) are predominantly regulated by TLR4, but others (IL-8 and TNF-alpha) are predominantly regulated by TLR2, due in part to TLR-dictated changes in transcription factor/promoter association. TLR2 and TLR9 also regulate B cell TLR4 expression, demonstrating that TLR cross-talk controls B cell responses at multiple levels. Parallel examination of B cells from periodontal disease and diabetes patients suggested that outcomes of TLR cross-talk are influenced by disease pathology. We co...Continue Reading

References

Nov 1, 1985·The Journal of Clinical Endocrinology and Metabolism·E FrazeG M Reaven
Aug 6, 1999·Immunity·T KawaiS Akira
Jun 23, 2000·Annals of Periodontology·G C Armitage
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S SatoS Akira
Mar 5, 2002·Clinical and Diagnostic Laboratory Immunology·George HajishengallisRobert J Genco
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Veit HornungGunther Hartmann
May 29, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ilham SeghrouchniAndré Revol
Aug 27, 2002·The Journal of Infectious Diseases·Andrew J DelimaDana T Graves
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Atsushi KosakiToshiji Iwasaka
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elize A HayashiAlberto Nobrega
Jun 25, 2005·American Heart Journal·Steven Offenbacher, James D Beck
Sep 29, 2005·Cellular Immunology·Pallave DasariHeddy Zola
Jan 28, 2006·The Journal of Biological Chemistry·Michael D LiangBarbara S Nikolajczyk
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Isabelle Bekeredjian-DingGunther Hartmann
Jun 13, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Lisa M Ganley-LealLee M Wetzler
Oct 21, 2006·The Journal of Clinical Investigation·Hang ShiJeffrey S Flier
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·André BoonstraAnne O'Garra
Dec 29, 2006·Annals of the New York Academy of Sciences·Niki M Moutsopoulos, Phoebus N Madianos
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aranya BagchiJudith Hellman
Feb 7, 2007·Molecular and Cellular Biology·Benoit GrondinTrang Hoang
Feb 24, 2007·Nature Reviews. Immunology·Giorgio Trinchieri, Alan Sher
Apr 13, 2007·The New England Journal of Medicine·Claus M LarsenMarc Y Donath
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
Apr 28, 2007·Primary Dental Care : Journal of the Faculty of General Dental Practitioners (UK)·Pauline J FordGregory J Seymour
May 10, 2007·Oral Microbiology and Immunology·R KikkertA J van Winkelhoff
Jun 30, 2007·Molecular Immunology·Gabi TheinerManfred B Lutz
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael DaveyCaroline A Genco
Mar 11, 2008·FEMS Immunology and Medical Microbiology·Ying SunAn-Ping Wu
Sep 17, 2008·Oral Microbiology and Immunology·A BeklenY T Konttinen
Oct 28, 2008·Molecular Immunology·Aude ThiriotDominique Rueff-Juy

❮ Previous
Next ❯

Citations

Apr 13, 2010·Diabetologia·M JagannathanB S Nikolajczyk
Jan 26, 2012·Mucosal Immunology·D FarquharsonS Culshaw
Jun 29, 2010·Pediatric Research·Joshua E PetrikinWilliam E Truog
Feb 5, 2011·The American Journal of Tropical Medicine and Hygiene·Daniel OnguruLisa Ganley-Leal
Mar 11, 2011·Genes and Immunity·B S NikolajczykR Gyurko
Sep 26, 2012·Journal of Periodontology·Nawarat Wara-aswapatiYuichi Izumi
Mar 8, 2012·Obesity·Marie E McDonnellCaroline M Apovian
Dec 19, 2014·The International Journal of Neuropsychopharmacology·Janelle Drouin-OuelletFrancesca Cicchetti
Jan 25, 2017·Journal of Neuroinflammation·Vibha ShuklaKunjan R Dave
Apr 28, 2012·Journal of Dental Research·R TamaiY Kiyoura
Mar 21, 2013·Inflammatory Bowel Diseases·Mian Qasim RehmanLisa Ganley-Leal
Sep 2, 2010·Inflammatory Bowel Diseases·Marie McDonnellLisa M Ganley-Leal
Nov 18, 2017·Scientific Reports·Denise RisnikMirta Giordano
May 29, 2013·American Journal of Rhinology & Allergy·Ludger KlimekJoerg Willers
Feb 28, 2015·Current Treatment Options in Allergy·Thomas M KündigMartin F Bachmann
May 27, 2015·PloS One·Hilana Paula Carillo ArteseGiuseppe Alexandre Romito
Nov 20, 2018·Medicinal Research Reviews·Muhammad Ayaz AnwarSangdun Choi
May 23, 2014·Immunologic Research·Claire M Buchta, Gail A Bishop
Nov 23, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L E P M van der VlugtH H Smits
Aug 8, 2015·Periodontology 2000·Hatice Hasturk, Alpdogan Kantarci
Oct 4, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michela SpadaroFederica Cavallo
Apr 1, 2020·International Journal of Molecular Sciences·Maria Antonietta PanaroChiara Porro
Sep 14, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raphael SchneiderNathalie Arbour
Aug 28, 2019·Experimental and Therapeutic Medicine·Weijuan QiBuling Wu
Feb 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manoj ThapaArash Grakoui
Jun 16, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L KlimekM F Bachmann
Aug 15, 2012·Immunological Reviews·Barbara S NikolajczykGerald V Denis
Jun 6, 2014·Expert Review of Clinical Immunology·Ludger KlimekThomas M Kündig
Aug 12, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Katherine J StrisselBarbara S Nikolajczyk
Dec 14, 2018·Allergo Journal International·Ludger KlimekMartin Bachmann
Nov 23, 2019·BMC Complementary and Alternative Medicine·Simin TianBaosheng Zhao
Aug 17, 2019·International Journal of Molecular Sciences·C M FigueredoR M Love
Mar 27, 2012·Immunology·Edward P Browne
Nov 28, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Benu GeorgeNitish Bhatia
Sep 27, 2014·Life Sciences in Space Research·Ann R Kennedy

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

Related Papers

Journal of Leukocyte Biology
Ansu Mammen NoronhaLisa M Ganley-Leal
European Journal of Immunology
David A van HeelRaymond J Playford
Proceedings of the National Academy of Sciences of the United States of America
Jason DeFuriaBarbara S Nikolajczyk
© 2022 Meta ULC. All rights reserved