TLR2 deficiency attenuates skeletal muscle atrophy in mice

Biochemical and Biophysical Research Communications
Dae-Sung KimSo-Young Park

Abstract

Oxidative stress and inflammation are associated with skeletal muscle atrophy. Because the activation of toll-like receptor (TLR) 2 induces oxidative stress and inflammation, TLR2 may be directly linked to skeletal muscle atrophy. This study examined the role of TLR2 in skeletal muscle atrophy in wild-type (WT) and TLR2 knockout (KO) mice. Immobilization for 2 weeks increased the expression of cytokine genes and the levels of carbonylated proteins and nitrotyrosine in the skeletal muscle, but these increases were lower in the TLR2 KO mice. Muscle weight loss and a reduction in treadmill running times induced by immobilization were also attenuated in TLR2 KO mice. Furthermore, immobilization increased the protein levels of forkhead box O 1/3, atrogin-1 and muscle ring finger 1 in the WT mice, which was attenuated in TLR2 KO mice. In addition, immobilization-associated increases in ubiquitinated protein levels were lower in the TLR2 KO mice. Immobilization increased the phosphorylation of Akt and p70S6K similarly in WT and KO mice. Furthermore, cardiotoxin injection into the skeletal muscle increased the protein levels of atrogin-1, interleukin-6, and nitrotyrosine and increased the levels of ubiquitinated proteins, although thes...Continue Reading

References

Jun 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·J E Fletcher, M S Jiang
Jan 10, 2002·Biochemical and Biophysical Research Communications·Per-Olof HasselgrenJoshua Mammen
Sep 10, 2004·American Journal of Physiology. Cell Physiology·Robert W Jackman, Susan C Kandarian
Apr 6, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Harold A Franch, S Russ Price
May 3, 2005·Biological & Pharmaceutical Bulletin·Masuhiro Nishimura, Shinsaku Naito
Jul 19, 2005·The Journal of Clinical Investigation·Liliana SchaeferHermann-Josef Gröne
Mar 23, 2007·Medical Hypotheses·Peng ZhangMing Fan
Jun 23, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Florian L MullerHolly Van Remmen
Jul 10, 2008·American Journal of Physiology. Endocrinology and Metabolism·David S WaddellSue C Bodine
Dec 6, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Lydie CombaretDidier Attaix
Mar 12, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J E DavisM E Spurlock
Apr 4, 2009·Journal of Applied Physiology·Annabelle Z CaronGuillaume Grenier
Jun 13, 2009·Journal of Applied Physiology·Heather M ArgadineGary C Sieck
Aug 19, 2009·Antioxidants & Redox Signaling·Esther Barreiro, Sabah N A Hussain
Apr 20, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·David J Glass
May 19, 2010·International Journal of Molecular Sciences·Si-Jin Meng, Long-Jiang Yu
Jul 2, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Z L Chang
Aug 17, 2011·BMC Musculoskeletal Disorders·Annabelle Z CaronGuillaume Grenier
Sep 20, 2011·Free Radical Biology & Medicine·Alexandra KadlNorbert Leitinger
Jan 31, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John M LawlerDaniel A Martinez
Oct 3, 2014·Journal of Molecular Signaling·Ann-Kristin FjällströmSven Tågerud

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Citations

Feb 10, 2016·PloS One·Jennifer M PetrosinoOuliana Ziouzenkova
Jan 12, 2017·International Journal of Molecular Sciences·Eun Ju LeeInho Choi
Oct 5, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eun Ju LeeInho Choi
Nov 23, 2017·The World Journal of Men's Health·Seong Yul RyuYong Woon Kim
Apr 14, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eun Ju LeeInho Choi
Sep 20, 2020·Scandinavian Journal of Medicine & Science in Sports·Miriam Martinez-CantonJose A L Calbet
Sep 7, 2019·International Journal of Molecular Sciences·Chenglin MoMarco Brotto
Mar 16, 2017·Histochemistry and Cell Biology·Eustáquio Luiz Paiva-OliveiraJussara Lagrota-Candido

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