TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Ivan PerrotChristophe Caux

Abstract

Cross-talk between NK cells and dendritic cells (DCs) is critical for the potent therapeutic response to dsRNA, but the receptors involved remained controversial. We show in this paper that two dsRNAs, polyadenylic-polyuridylic acid and polyinosinic-polycytidylic acid [poly(I:C)], similarly engaged human TLR3, whereas only poly(I:C) triggered human RIG-I and MDA5. Both dsRNA enhanced NK cell activation within PBMCs but only poly(I:C) induced IFN-gamma. Although myeloid DCs (mDCs) were required for NK cell activation, induction of cytolytic potential and IFN-gamma production did not require contact with mDCs but was dependent on type I IFN and IL-12, respectively. Poly(I:C) but not polyadenylic-polyuridylic acid synergized with mDC-derived IL-12 for IFN-gamma production by acting directly on NK cells. Finally, the requirement of both TLR3 and Rig-like receptor (RLR) on mDCs and RLRs but not TLR3 on NK cells for IFN-gamma production was demonstrated using TLR3- and Cardif-deficient mice and human RIG-I-specific activator. Thus, we report the requirement of cotriggering TLR3 and RLR on mDCs and RLRs on NK cells for a pathogen product to induce potent innate cell activation.

References

Jan 1, 1989·Advances in Immunology·G Trinchieri
Jun 11, 1999·The Journal of Biological Chemistry·R SchwandnerC J Kirschning
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y YuS Kato
Feb 6, 2002·The Journal of Experimental Medicine·Franca GerosaGiorgio Trinchieri
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Dec 24, 2002·Nature Immunology·Daniel M AndrewsMariapia A Degli-Esposti
Feb 4, 2003·Nature Reviews. Immunology·Giorgio Trinchieri
Jun 7, 2003·Science·Stephen E GirardinDana J Philpott
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robbie B MailliardPawel Kalinski
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerstin N SchmidtPaul J Godowski
Jun 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Simona SivoriAlessandro Moretta
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Aug 4, 2004·The Journal of Experimental Medicine·Francesca GranucciPaola Ricciardi-Castagnoli
Nov 9, 2004·Nature Immunology·Alfonso Martín-FontechaFederica Sallusto
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Franca GerosaGiorgio Trinchieri
Jun 4, 2005·Blood·Thierry WalzerEric Vivier
Jan 13, 2006·Nature·Thirumala-Devi KannegantiGabriel Núñez
Oct 14, 2006·Science·Andreas PichlmairCaetano Reis e Sousa
Oct 14, 2006·Science·Veit HornungGunther Hartmann
Dec 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Takashi AkazawaTsukasa Seya
Apr 3, 2007·Immunity·Mathias LucasAndreas Diefenbach
Jun 2, 2007·Cell Death and Differentiation·A MorettaL Moretta
Jan 16, 2008·The Journal of Experimental Medicine·Zhengkun TuMark S Orloff
Feb 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Christine TrumpfhellerRalph M Steinman
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacob S YountCarolina B López
Apr 29, 2008·Immunity·Marie-Cécile MichalletJürg Tschopp
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tohru MiyakeShizuo Akira
Dec 10, 2009·The Journal of Experimental Medicine·Stephen McCartneyMarco Colonna

❮ Previous
Next ❯

Citations

Dec 15, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kirstin M HeutinckAjda T Rowshani
Apr 26, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Danielle N VanJessica K Bell
May 22, 2013·Infection and Immunity·Komi GbédandéAdrian J F Luty
Nov 23, 2011·Molecular Medicine·Fernando Souza-Fonseca-GuimaraesJean-Marc Cavaillon
Jan 25, 2013·Viruses·Irene Ramos, Ana Fernandez-Sesma
Dec 25, 2013·Immunology and Cell Biology·Minou Adib-ConquyFernando Souza-Fonseca-Guimaraes
Feb 19, 2013·Expert Opinion on Therapeutic Targets·Tsukasa SeyaMisako Matsumoto
May 2, 2014·Frontiers in Immunology·Guido Ferlazzo, Barbara Morandi
May 31, 2016·Cellular & Molecular Immunology·Yinli YangJian Zhang
Oct 14, 2014·Expert Review of Vaccines·Karen Ao MartinsAndres M Salazar
Mar 18, 2011·Journal of Innate Immunity·Rebekka WehnerMarc Schmitz
Jan 22, 2013·Arthritis and Rheumatism·Marta RadwanDavid A Young
Oct 26, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Diwakar DavarHassane M Zarour
Sep 20, 2018·International Journal of Cancer. Journal International Du Cancer·Juliane Daßler-PlenkerChristoph Coch
Mar 9, 2012·Targeted Oncology·Nadège GoutagnyChristophe Caux
Mar 3, 2012·Langenbeck's Archives of Surgery·Rebecca Kesselring, Stefan Fichtner-Feigl
Sep 17, 2020·Oncoimmunology·Julie Le NaourErika Vacchelli
Jul 22, 2014·International Journal of Cancer. Journal International Du Cancer·Florence DeauvieauJenny Valladeau-Guilemond
Oct 17, 2013·Expert Review of Clinical Immunology·Rohit Gaurav, Devendra K Agrawal
Feb 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·David Andrés NoceraMariana Maccioni
Nov 6, 2015·Journal of Leukocyte Biology·Monica CappellettiSenad Divanovic
Nov 16, 2010·International Reviews of Immunology·Marla Karine Amarante, Maria Angelica Ehara Watanabe
Jun 26, 2020·Frontiers in Immunology·Maaike R ScheenstraMaarten Coorens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.