TLR5 and TLR7 are differentially expressed in human papillomavirus-positive and negative base of tongue squamous cell carcinoma, and TLR7 may have an independent prognostic influence

Acta Oto-laryngologica
Linnea HaeggblomTina Dalianis

Abstract

Human papillomavirus-positive (HPV+) base of tongue squamous cell carcinoma (BOTSCC) has a better outcome than corresponding HPV- cancer. TLR5 and TLR7 expression was previously shown to differ depending on HPV - status and correlate with outcome in oropharyngeal squamous cell carcinoma. For validation, TLR5 and TLR7 were analyzed in a BOTSCC-cohort for correlation with HPV, survival, CD4+ and CD8+ tumor-infiltrating lymphocyte (TIL) counts, the latter being a well-documented prognostic marker. BOTSCC biopsies, (49HPV+/28HPV-) were analyzed by immunohistochemistry for TLR5 and TLR7, and correlated with the above parameters. TLR5 expression was more frequently absent/weak than medium/strong in HPV+ compared to HPV- BOTSCC (p < .001). The opposite was observed for TLR7 (p < .007). TLR5 and TLR7 expression did not correlate to survival in either the HPV- or HPV+ cases, or to CD4+ TILs. TLR5, (but not TLR7) expression was correlated to CD8+ TIL counts (p = .023). Absent/weak TLR5 and medium/strong TLR7 expression was validated as more frequent in HPV+ compared with HPV- BOTSCC. A correlation between CD8+ TIL counts, and TLR5 expression was disclosed, but not with TLR7. Therefore, it could be useful to investigate TLR7 further as a ...Continue Reading

References

Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·C A Janeway
Jun 14, 2005·Current Opinion in Immunology·Taro Kawai, Shizuo Akira
Aug 8, 2007·International Journal of Cancer. Journal International Du Cancer·Serge J SmeetsRuud H Brakenhoff
Mar 31, 2009·International Journal of Cancer. Journal International Du Cancer·Anders NäsmanTina Dalianis
Aug 21, 2010·International Journal of Cancer. Journal International Du Cancer·Per AttnerEva Munck-Wikland
Apr 11, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Cecilia NordforsTina Dalianis
Mar 14, 2014·International Journal of Cancer. Journal International Du Cancer·H MirghaniJ Lacau St Guily
Dec 4, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anders NäsmanTina Dalianis
May 6, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lauri JouhiJaana Hagström
May 31, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nikolaos TertipisTina Dalianis

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Citations

May 1, 2020·Journal of Oncology·Hongjiao WuXuemei Zhang
Oct 4, 2020·International Journal of Molecular Sciences·Shrabon HasnatAbdelhakim Salem
Aug 12, 2021·Journal of Cellular and Molecular Medicine·Xueling WangQibao Wang

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