TLR9 -1237 T/C and TLR2 -194 to -174 del polymorphisms and the risk of Parkinson's disease in the Greek population: a pilot study.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Kallirhoe KalinderiLiana Fidani

Abstract

Toll-like receptors (TLRs) are important mediators of inflammatory responses by recognition of many pathogen-related molecules and endogenous proteins related to immune activation. Accumulating data have recently pointed out the role of neuroinflammation in Parkinson's disease (PD) pathogenesis. In the present study, we investigated the potential role of the TLR9 -1237 T/C and TLR2 -194 to -174 del polymorphisms in PD. We studied a total of 333 individuals, 215 Greek patients with sporadic PD and 118 control subjects, using a polymerase chain reaction-restriction fragment length polymorphism method. No statistically significant differences were found between PD patients and control subjects for the TLR9 -1237 T/C genotypes or alleles. Regarding the TLR2 -196 to -174 del polymorphism, the del/del genotype and the del allele were overrepresented in the PD group compared to controls, however, this result did not reach statistical significance (P = 0.087). Further studies investigating the TLR-inflammatory background of PD are awaited to provide important insight into the aetiology of the disease.

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Feb 28, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E NoguchiT Arinami
Dec 9, 2004·International Immunology·Kiyoshi Takeda, Shizuo Akira
Aug 30, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lutz HamannRalf R Schumann
Jul 2, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Z L Chang
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Melinda E Lull, Michelle L Block
Jan 19, 2011·Biochemical Pharmacology·Michael Carty, Andrew G Bowie
Apr 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Francisco Ros-BernalSheela Vyas
Jul 8, 2011·Current Opinion in Neurology·Alexander Zimprich
Jul 13, 2011·Frontiers in Neuroscience·Dawn BéraudKathleen A Maguire-Zeiss

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Citations

Feb 8, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiong DaiZhi Hui Yang
May 23, 2015·The International Journal of Neuroscience·Konghua ZhuAnmu Xie
Mar 3, 2015·International Journal of Immunogenetics·M LewandowskaH Witas
Mar 1, 2017·Frontiers in Neurology·Carmen D RietdijkAletta D Kraneveld
Oct 20, 2018·Frontiers in Cellular Neuroscience·Bernd L FiebichAntonio Carlos Pinheiro de Oliveira
Oct 14, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zhang PingShao Liang

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