TLR9 agonist CpG enhances protective nasal HSP60 peptide vaccine efficacy in experimental autoimmune arthritis

Annals of the Rheumatic Diseases
Evelien Zonneveld-HuijssoonBerent J Prakken

Abstract

Peptide-based immune tolerance induction is considered an attractive treatment option for autoimmune diseases. The authors have developed a novel method that can enhance the induction of protective peptide-specific T-cell responses, using a rat arthritis model. The authors focused on the Toll-like receptor 9 ligand CpG, which was shown to stimulate regulatory T-cell proliferation when added to plasmacytoid dendritic cells (pDC) using in-vitro cultures. The peptide used is a heat shock protein 60 epitope (p1) that elicits tolerogenic peptide-specific immune responses in human arthritis patients and was recently shown to have protective capacity as a bystander antigen in the rat adjuvant arthritis model. Rats were treated with three nasal doses of p1, CpG or a combination of p1 and CpG. Antigen-presenting cells were studied in nose-draining lymph nodes (mandibular lymph nodes; MLN) after nasal treatment, and T-cell responses were analysed in joint-draining lymph nodes after arthritis induction. Nasal co-administration of p1/CpG significantly augmented the arthritis-protective effect of p1, while CpG treatment alone did not. Co-treatment of p1/CpG increased both the number and activation status of pDC in draining MLN, which was ac...Continue Reading

Citations

Sep 27, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·John E McKinnon, Kathleen Maksimowicz-McKinnon
Aug 19, 2015·Scientific Reports·Young Mee YoonBenjamin G Keselowsky
Aug 21, 2013·Human Vaccines & Immunotherapeutics·Lingxiao ZhaoHua Cong
Apr 28, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jih-Yang KoFeng-Sheng Wang
Dec 10, 2016·Human Vaccines & Immunotherapeutics·Helmy Yusuf, Vicky Kett
Aug 1, 2013·Physiological Reviews·Paul N Hopkins
Dec 14, 2019·Immunological Reviews·Miika ArvonenMatthew L Stoll
Jan 15, 2013·ChemMedChem·Peter Michael Moyle, Istvan Toth
Jul 4, 2020·Nature Reviews. Materials·C L StablerB G Keselowsky
Apr 8, 2020·Journal of Immunology Research·Bin WangGuixiu Shi
Oct 20, 2020·Frontiers in Immunology·Guilherme Gusmao-SilvaAna Maria Caetano Faria

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