TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine

Expert Review of Vaccines
Cevayir CobanKen J Ishii

Abstract

Vaccination has been a successful tool in the protection against many infectious diseases, and recent advances in biotechnology have created new techniques and strategies to produce safe and efficacious vaccines for human use. However, developing a protective vaccine against malaria has been a challenge. In this article, we focus on an old approach with some new modifications, the so-called whole-parasite vaccination strategy against blood-stage Plasmodium falciparum, the deadliest human malarial agent. In addition, we discuss recent developments in our understanding of how the endogenous adjuvant activity in the parasites, which functions via Toll-like receptor 9, acts as a double-edged sword between protective vaccination and pathological responses against malaria infection.

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Citations

Apr 11, 2013·International Reviews of Immunology·Julien Pothlichet, Lluis Quintana-Murci
May 9, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Jin LiuTsung-Hsien Chuang
Apr 3, 2012·Scientific Reports·Alicia D HennMartin S Zand
Apr 12, 2019·Parasite Immunology·Ann M MoormannCatherine S Forconi

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