PMID: 22553782May 4, 2012Paper

TLR9-mediated signals rescue B-cells from Fas-induced apoptosis via inactivation of caspases

Immunology Letters
Anikó HanczGabriella Sármay

Abstract

The death receptor, CD95/Fas, serves to eliminate potentially dangerous, self-reactive B cells. Engagement of B-cell receptors (BCR) on mature B-cells mediates the escape from cell death resulting in the activation and expansion of antigen specific clones. In addition to the antigen receptors, the receptors of B-cell activating factor belong to the tumor necrosis factor (TNF) family (BAFFR); moreover, the pattern recognition receptor, TLR9 may also deliver survival signals inhibiting Fas-mediated death of B-cells. Our aim was to compare the mechanism of BCR-induced and the BAFFR- or TLR9-stimulated rescue of B-cells from CD95/Fas-mediated apoptosis. We have found that BAFFR and TLR9 collaborate with BCR to protect B-cells from Fas-induced elimination and the rescue is independent of protein synthesis. The results revealed that the TLR9- and BCR-triggered rescue signals are transmitted through partially overlapping pathways; the protein kinase C (PKC) and the abl kinase induced phosphorylation may inactivate caspases in both CpG and anti-IgG stimulated cells. However, PI3-K activation is crucial upon the BCR driven anti-apoptotic effect, while p38 MAPK-mediated inactivation of caspases seems to play essential role in TLR9-mediat...Continue Reading

References

Sep 22, 1995·The Journal of Biological Chemistry·A J McGahonD R Green
Nov 1, 1995·Current Biology : CB·J C Rathmell, C C Goodnow
Apr 1, 1997·Current Opinion in Immunology·Y J LiuI Fugier-Vivier
Apr 1, 1997·Immunological Reviews·Y J Liu, C Arpin
Dec 22, 1999·European Journal of Immunology·J WangM J Lenardo
Jan 8, 2000·International Reviews of Immunology·J Wang, T Watanabe
Oct 24, 2000·Immunological Reviews·G B CareyD W Scott
Feb 24, 2001·Cell Research·T L Rothstein
Oct 3, 2001·The Journal of Biological Chemistry·M Gómez-Angelats, J A Cidlowski
Feb 6, 2002·Springer Seminars in Immunopathology·E M Fuentes-Pananá, J G Monroe
May 25, 2002·The Journal of Biological Chemistry·Andrea L WursterMichael J Grusby
Jul 3, 2002·Nature Reviews. Immunology·Fabienne Mackay, Jeffrey L Browning
Oct 18, 2003·Seminars in Immunology·Ignacio Moreno de AlboránCarlos Martínez-A
Feb 14, 2004·Immunological Reviews·Michael P Cancro
Feb 19, 2004·The Journal of Experimental Medicine·Maria Alvarado-KristenssonTommy Andersson
Jan 20, 2005·The Journal of Biological Chemistry·Deepak RainaDonald Kufe
May 12, 2005·Current Opinion in Immunology·Stanford L Peng
Nov 23, 2005·The Journal of Experimental Medicine·Andrew CraxtonEdward A Clark
May 26, 2006·The New England Journal of Medicine·Mark J Smyth
Dec 6, 2006·Annals of the New York Academy of Sciences·Marc S LamphierEicke Latz
Mar 16, 2007·European Journal of Immunology·Eva V Acosta-RodríguezAdriana Gruppi
Aug 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kevin L OtipobyKlaus Rajewsky
Aug 26, 2009·Nature Reviews. Immunology·Michael P Cancro
Sep 10, 2009·Cell·Manabu Kurokawa, Sally Kornbluth
Oct 23, 2009·Journal of Autoimmunity·Marie-Laure Santiago-RaberShozo Izui
Oct 25, 2011·Immunological Reviews·Robert C RickertAna V Miletic

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Citations

Jan 23, 2016·Molecular Immunology·Reza YazdaniAsghar Aghamohammadi
Aug 15, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Angela MensenIl-Kang Na
Apr 15, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Falk SaupeLars Hellman

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