TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Sandra L SiedlakXinglong Wang

Abstract

Transmembrane Protein 230 (TMEM230) is a newly identified protein associated with Parkinson's disease (PD) found in Lewy bodies and Lewy neurites of patients with PD or dementia with Lewy body disease. However, TMEM230 has not yet been investigated in the most common neurodegenerative disorder, Alzheimer's disease (AD). Here, we demonstrate that the expression of TMEM230 is specifically increased in neurons in AD patients. Importantly, both granulovacuolar degeneration (GVD) and dystrophic neurites (DNs), two prominent characteristic pathological structures associated with AD, contain TMEM230 aggregates. TMEM230 immunoreactivity can be detected in neurofibrillary tangles-containing neurons and hyperphosphorylated tau positive DNs. TMEM230 accumulation is also noted around senile plaques. These findings identifying TMEM230 as a component of GVD and DNs suggest TMEM230 dysregulation as a likely mechanism playing an important role in the pathogenesis of AD.

References

May 1, 1977·Journal of Neuropathology and Experimental Neurology·M J Ball, P Lo
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P CrasG Perry
Jan 1, 1991·Acta Neuropathologica·K OkamotoM Watanabe
Feb 26, 1998·International Review of Neurobiology·M A Smith
Jul 31, 2003·Proceedings of the National Academy of Sciences of the United States of America·T Chris GamblinVincent L Cryns
Mar 9, 2005·Journal of Neuropathology and Experimental Neurology·Ralph A NixonAna Maria Cuervo
May 31, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Inmaculada Cuchillo-IbanezDiane P Hanger
Jan 10, 2012·Cold Spring Harbor Perspectives in Medicine·Alberto Serrano-PozoBradley T Hyman
Apr 15, 2015·Reviews in the Neurosciences·Ameneh Zare-ShahabadiNima Rezaei
Sep 1, 2015·Alzheimer's Research & Therapy·Sally HunterUNKNOWN Cambridge City over-75s Cohort Collaboration
Jun 9, 2016·Nature Genetics·Han-Xiang DengTeepu Siddique
Jun 28, 2016·Nature Medicine·Wenzhang WangXinglong Wang

❮ Previous
Next ❯

Citations

Sep 5, 2020·Acta Neuropathologica Communications·Vera I WiersmaWiep Scheper
Nov 20, 2020·Neuroscience·Xiaobo WangWanli W Smith
Sep 28, 2021·Translational Neurodegeneration·Neus BarrancoFernando Aguado
Dec 16, 2021·Science Advances·Thanaphong PhongpreechaThomas J Montine

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.