TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury

The American Journal of Pathology
Emad ArafaNader Rahimi

Abstract

Oxidative damage to renal tubular epithelial cells is a fundamental pathogenic mechanism implicated in both acute kidney injury and chronic kidney diseases. Because epithelial cell survival influences the outcome of acute kidney injury and chronic kidney diseases, identifying its molecular regulators could provide new insight into pathobiology and possible new therapeutic strategies for these diseases. We have identified transmembrane and immunoglobulin domain-containing 1 (TMIGD1) as a novel adhesion molecule, which is highly conserved in humans and other species. TMIGD1 is expressed in renal tubular epithelial cells and promotes cell survival. The extracellular domain of TMIGD1 contains two putative immunoglobulin domains and mediates self-dimerization. Our data suggest that TMIGD1 regulates transepithelial electric resistance and permeability of renal epithelial cells. TMIGD1 controls cell migration, cell morphology, and protects renal epithelial cells from oxidative- and nutrient-deprivation-induced cell injury. Hydrogen peroxide-induced oxidative cell injury downregulates TMIGD1 expression and targets it for ubiquitination. Moreover, TMIGD1 expression is significantly affected in both acute kidney injury and in deoxy-corti...Continue Reading

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Citations

Nov 14, 2016·Journal of Molecular Biology·Yun Hwa Walter WangNader Rahimi
Jan 13, 2018·Journal of Molecular Cell Biology·Rachel Xi-Yeen HoNader Rahimi
Jan 13, 2018·Frontiers in Immunology·Nader Rahimi
Oct 12, 2018·The Journal of Reproduction and Development·Hsiu-Lin HuangYu-Shin Cheng
Aug 2, 2018·International Journal of Molecular Medicine·Xueqing ZouJun Niu
Sep 11, 2021·Journal of Biomedical Science·Nader RahimiCatherine E Costello

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