TMPO-AS1 is an independent prognostic factor for patients with laryngeal squamous cell carcinoma

Revista da Associação Médica Brasileira
Lihua ZhangFang Tian

Abstract

OBJECTIVE Long noncoding RNA (lncRNAs) are frequently abnormally expressed in tumors and involved in the occurrence and progression of human cancer. Recently, a disease-related lncRNA, TMPO antisense RNA 1 (TMPO-AS1), was identified to be dysregulated in several tumors. Hence, we aimed to demonstrate whether TMPO-AS1 could be a promising prognostic marker for patients with laryngeal squamous cell carcinoma (LSCC). METHODS RT-PCR was performed to test TMPO-AS1 expressions in 187 LSCC specimens compared with matched normal specimens. Chi-squared tests were used to determine the associations between TMPO-AS1 expressions and the clinicopathological characteristics of LSCC patients. Then, the clinical outcome of LSCC patients who had lower or higher TMPO-AS1 expression was analyzed using Kaplan-Meier assays. Finally, a Cox proportional hazards model was carried out to evaluate the prognostic values of TMPO-AS1 and other clinical features. RESULTS We found that TMPO-AS1 was distinctly upregulated in human LSCC tissues compared with corresponding normal specimens (p < 0.01). Higher expressions of TMPO-AS1 were observed to be positively associated with the clinical stage (p = 0.020) and lymph node metastasis (p = 0.027). A clinical stu...Continue Reading

References

Apr 6, 2004·Surgical Oncology Clinics of North America·Pablo Mojica-ManosaWade Douglas
Mar 15, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Giovanni AlmadoriMaurizio Maurizi
Jun 20, 2015·Journal of Immunology Research·Keshav Raj SigdelYanLin Zhang
Aug 25, 2015·Biochimica Et Biophysica Acta·Brian S Gloss, Marcel E Dinger
Dec 4, 2015·Annual Review of Genetics·Victoria H MellerNikita Deshpande
Mar 6, 2016·Mayo Clinic Proceedings·Shanthi Marur, Arlene A Forastiere
Jul 16, 2016·FEBS Letters·Sergio Leone, Raffaella Santoro
Aug 23, 2016·The Laryngoscope·Evren ErkulMustafa A Babayigit
Feb 6, 2017·Surgical Pathology Clinics·Lester D R Thompson
Apr 6, 2017·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Eric WinquistUNKNOWN Head and Neck Disease Site Group
Jun 24, 2017·Auris, Nasus, Larynx·Qicheng ZhangRenjie Chen
Aug 18, 2017·Advances in Experimental Medicine and Biology·Arun Renganathan, Emanuela Felley-Bosco

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