TNF-α and TNF-β Gene Polymorphism in Saudi Rheumatoid Arthritis Patients

Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
Hannan Al-RayesMohammad Tariq

Abstract

Tumor necrosis factor (TNF)-α and -β are cytokines with a wide range of inflammatory, apoptotic and immunomodulatory activities. TNF-α promoter -308 G < A polymorphism has been reported to be associated with rheumatoid arthritis (RA) with inconsistent results. The aim of this study is to elucidate a possible association of TNF-α (G-308A) and TNF-β (A+252G) polymorphisms with the susceptibility of RA in Saudi patients. This case control study consisted of 232 Saudi subjects including 106 RA patients and 126 matched controls. Genomic DNA was extracted using QIAamp(R) DNA mini kit (Qiagen CA, USA). TNF-α and TNF-β genes were amplified using Arms primers. The frequencies of TNF-α (-308) allele G and genotype GG were significantly higher in RA patients as compared to controls while allele A and genotype AA were predominant in control group. On the other hand the frequency of TNF-β (+252) GG and AA genotypes were significantly higher in RA patients as compared to controls while GA genotype was predominant in controls. It was inferred that genotype GG positive individuals at position -308 of TNF-α were susceptible to RA while genotype AA might has a protective effect on RA susceptibility in Saudis. Whereas GG and AA genotype of TNF-β ...Continue Reading

References

Dec 7, 2013·Rheumatology International·Gwan Gyu SongYoung Ho Lee
Aug 22, 2018·Journal of Clinical Laboratory Analysis·Kaan YerliyurtSerbulent Yigit
May 3, 2019·Clinical and Experimental Medicine·Fabiano Aparecido de MedeirosAndréa Name Colado Simão
Jan 14, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Deependra K YadavAloukick K Singh
Jun 12, 2018·Biomarker Insights·Ghaleb Bin HuraibAbdulrahaman Al-Asmari
Oct 8, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C H MaC Q Yi

Citations

May 1, 1992·British Journal of Rheumatology·F M BrennanM Feldmann
Jan 1, 1989·Annual Review of Immunology·B Beutler, A Cerami
Jan 1, 1983·Immunological Reviews·A SvejgaardL P Ryder
Apr 1, 1993·Clinical and Experimental Immunology·L J AbrahamR L Dawkins
Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology·K U SchallreuterJ Berger
Jan 1, 1997·Tissue Antigens·J VinascoJ Martín
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A G WilsonG W Duff
Jun 30, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R V AlbuquerqueP N Lesouëf
Feb 9, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·G ZelanoP A Tonali
Aug 18, 1999·JAMA : the Journal of the American Medical Association·J P MiraJ F Dhainaut
Aug 24, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·A N AbdallahA Iron
Dec 22, 1999·Human Immunology·J P Pandey, F Takeuchi
Aug 23, 2000·Metabolism: Clinical and Experimental·S C LeeJ C Chan
Feb 24, 2001·Archives of Dermatological Research·V VaskůV Semrádová
May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·R RosmondP Björntorp
Jan 17, 2002·Current Directions in Autoimmunity·M FeldmannR N Maini
Dec 2, 2004·Acta Microbiologica Et Immunologica Hungarica·A BalogYvette Mándi
Aug 13, 2005·Scandinavian Journal of Rheumatology·A PawlikM Herczynska
May 5, 2006·Rheumatology International·Ramiz Al-SwailemMohammad Tariq
Sep 4, 2007·Rheumatology International·Zahra RezaieyazdiFarnaz Mohajer

Related Concepts

Gene Polymorphism
Necrosis
Exertion
Tumor Necrosis Factor-alpha
Articular System
Promoter
Joints
Rheumatoid Arthritis
Genomic DNA
Cytokine

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.