TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise

Frontiers in Physiology
Jeremy R TownsendJeffrey R Stout

Abstract

The purpose of this investigation was to compare the effect of two commonly used therapeutic modalities (a) neuromuscular electrical stimulation (NMES) and (b) cold water immersion (CWI) on circulating tumor necrosis factor alpha (TNF-α) and monocyte TNF-α receptor (TNFR1) expression following intense acute resistance exercise and subsequent recovery. Thirty (n = 30) resistance trained men (22.5 ± 2.7 y) performed an acute heavy resistance exercise protocol on three consecutive days followed by one of three recovery methods (CON, NMES, and CWI). Circulating TNF-α levels were assayed and TNFR1 expression on CD14+ monocytes was measured by flow cytometry measured PRE, immediately post (IP), 30-min post (30M), 24 h post (24H), and 48 h post (48H) exercise. Circulating TNF-α was elevated at IP (p = 0.001) and 30M (p = 0.005) and decreased at 24H and 48H recovery from IP in CON (p = 0.015) and CWI (p = 0.011). TNF-α did not significantly decrease from IP during recovery in NMES. TNFR1 expression was elevated (p < 0.001) at 30M compared to PRE and all other time points. No significant differences between groups were observed in TNFR1 expression. During recovery (24H, 48H) from muscle damaging exercise, NMES treatment appears to preve...Continue Reading

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Citations

Dec 5, 2017·Journal of the International Society of Sports Nutrition·Justin RobertsMenno Henselmans
Jan 20, 2016·Medicine and Science in Sports and Exercise·Adam J WellsJeffrey R Stout
Jun 26, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lina MaPeter M Abadir
Jul 15, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ayoub SaeidiHassane Zouhal

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Methods Mentioned

BETA
blood draw
enzyme-linked immunosorbent assays
flow cytometry
Fluorescence

Software Mentioned

BD Accuri analysis software
SPSS

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