TNF-α, myocardial perfusion and function in patients with ST-segment elevation myocardial infarction and primary percutaneous coronary intervention.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Eva S KehmeierTienush Rassaf

Abstract

To characterize the time course of tumor necrosis factor-α (TNF-α) serum levels along with myocardial perfusion and contractile function in patients with ST-segment elevation myocardial infarction (STEMI) and successful primary percutaneous coronary intervention (PCI). Serum levels of TNF-α, interleukin 6 (IL-6), and C-reactive protein (CRP) were measured in 42 patients with STEMI before, one and 6 days after successful PCI. Myocardial perfusion was assessed by contrast-enhanced echocardiography (ceEcho), contractile function by unenhanced two-dimensional (2DE) and real-time three-dimensional echocardiography. In a subset of 18 patients, infarct size was quantified by late gadolinium enhancement cardiovascular magnetic resonance imaging (LGE-CMR) on day six. TNF-α serum levels were in the upper normal range within the first 12 h from symptom onset and increased continuously until day six, while IL-6 and CRP increased subsequently with a peak on day one after STEMI. Serum TNF-α on day one after PCI correlated with perfusion defects, wall motion abnormalities, and infarct size (ceEcho: r = 0.52, p = 0.005; 2DE: r = 0.56, p = 0.002; LGE-CMR: r = 0.83-0.86; p < 0.0001). Using multiple regression linear analysis, infarct size on day...Continue Reading

Associated Clinical Trials

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Citations

Oct 19, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jens WiebeHolger Nef
Dec 25, 2016·Expert Review of Cardiovascular Therapy·Fabien HuetFrançois Roubille
May 4, 2017·Journal of Translational Medicine·Elena Teringova, Petr Tousek
Jul 26, 2017·Clinical Reviews in Allergy & Immunology·Cristina Panico, Gianluigi Condorelli
Nov 28, 2018·Pharmacological Reports : PR·Ewelina KazimierczykAgnieszka Tycinska
Sep 11, 2019·Journal of Molecular and Cellular Cardiology·Yan DongJie Wang

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