PMID: 15240695Jul 9, 2004Paper

TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-kappaB activation, and apoptosis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Yasunari Takada, Bharat B Aggarwal

Abstract

Spleen tyrosine kinase (Syk), a nonreceptor protein kinase initially found to be expressed only in hemopoietic cells, has now been shown to be expressed in nonhemopoietic cells and to mediate signaling of various cytokines. Whether Syk plays any role in TNF signaling was investigated. Treatment of Jurkat T cells with TNF activated Syk kinase but not ZAP70, another member of Syk kinase family, and the optimum activation occurred at 10 s and with 1 nM TNF. TNF also activated Syk in myeloid and epithelial cells. TNF-induced Syk activation was abolished by piceatannol (Syk-selective inhibitor), which led to the suppression of TNF-induced activation of c- JNK, p38 MAPK, and p44/p42 MAPK. Jurkat cells that did not express Syk (JCaM1, JCaM1/lck) showed lack of TNF-induced Syk, JNK, p38 MAPK, and p44/p42 MAPK activation, as well as TNF-induced IkappaBalpha phosphorylation, IkappaBalpha degradation, and NF-kappaB activation. TNF-induced NF-kappaB activation was enhanced by overexpression of Syk by Syk-cDNA and suppressed when Syk expression was down-regulated by expression of Syk-small interfering RNA (siRNA-Syk). The apoptotic effects of TNF were reduced by up-regulation of NF-kappaB by Syk-cDNA, and enhanced by down-regulation of NF-k...Continue Reading

References

Jan 1, 1997·Annual Review of Immunology·J B Bolen, J S Brugge
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·I M Verma, J Stevenson
Jan 31, 1998·The EMBO Journal·T MoriguchiE Nishida
Jun 8, 1999·The Journal of Experimental Medicine·E Hildt, S Oess
Aug 3, 1999·The Journal of Clinical Investigation·M FuortesC Nathan
Jan 14, 2000·Journal of Clinical Immunology·P C Rath, B B Aggarwal
Feb 26, 2000·Immunology Today·M TurnerV L Tybulewicz
Jul 14, 2000·Nature·J L Pomerantz, D Baltimore
Jul 25, 2000·Methods in Enzymology·M M ChaturvediB B Aggarwal
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S K MannaB B Aggarwal
Mar 10, 2001·Biochemical and Biophysical Research Communications·H M Korchak, L E Kilpatrick
Jul 4, 2001·The Journal of Biological Chemistry·C S Shi, J H Kehrl
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S Majumdar, B B Aggarwal
May 1, 2002·Nature Biotechnology·Thomas Tuschl
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuhiro AshikawaBharat B Aggarwal
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei-Chien HuangChing-Chow Chen

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Citations

Apr 16, 2005·Cell Death and Differentiation·G IonE Monostori
Nov 18, 2005·The Journal of Biological Chemistry·Aristides G EliopoulosPhilip N Tsichlis
Sep 28, 2005·Expert Opinion on Therapeutic Targets·Marina UlanovaA Dean Befus
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Murali GururajanSubbarao Bondada
Jun 16, 2012·Journal of Neuroinflammation·Aedín M MinogueMarina A Lynch
Jun 27, 2012·The Journal of Cell Biology·Ssang-Taek LimDavid D Schlaepfer
Jul 24, 2018·Current Stem Cell Research & Therapy·Cong Tang, Guodong Zhu
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roxana PincheiraDavid B Donner
Apr 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie Gottar-GuillierBruno Cenni
Dec 10, 2013·Clinical and Experimental Immunology·H PattersonS Siebert
Oct 3, 2017·Immunotherapy·Adrian NewlandJames B Bussel
Feb 21, 2019·American Journal of Hematology·James B BusselAnne-Marie Duliege
Jul 20, 2019·Cell Death and Differentiation·Po-Han ChenJen-Tsan Chi
May 2, 2008·Expert Opinion on Investigational Drugs·Malini BajpaiAbhijit Ray
Sep 8, 2010·Intensive Care Medicine·Erica L Martin, V Marco Ranieri
May 9, 2006·Antioxidants & Redox Signaling·Hae Young ChungByung Pal Yu
Jul 11, 2007·Journal of Endotoxin Research·Marina UlanovaDean Befus
Jun 12, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tomoyuki MukaiYasuyoshi Ueki
Nov 24, 2017·Phytotherapy Research : PTR·Aldarmaa JalsraiAxel Becker
Feb 27, 2018·The Journal of Toxicological Sciences·Pattama SinghirunnusornMathuros Ruchirawat
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Murali GururajanSubbarao Bondada
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaomin WangChung-Wai Chow
Apr 19, 2012·Experimental Dermatology·Christophe ChapardMarcel Huber
Jan 29, 2014·Hematological Oncology·Frederic Carsten SchmeelIngo G H Schmidt-Wolf
Oct 12, 2017·Canadian Journal of Physiology and Pharmacology·Alaa AlhazmiMarina Ulanova
Jun 2, 2018·ChemMedChem·Noemi de J HillerDaniela de Luna Martins
Mar 20, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marilena PontorieroIleana Quinto
Apr 3, 2019·International Journal of Molecular Sciences·Eunji KimJae Youl Cho
Feb 3, 2006·The Journal of Pharmacology and Experimental Therapeutics·Hoon-Suk ChaGary S Firestein

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