TNF-alpha acutely inhibits vascular effects of physiological but not high insulin or contraction

American Journal of Physiology. Endocrinology and Metabolism
Lei ZhangStephen Rattigan

Abstract

TNF-alpha is elevated in many states of insulin resistance, and acutely administered TNF-alpha in vivo inhibits insulin-mediated hemodynamic effects and glucose uptake in muscle. In this study, we assess whether the inhibitory effects of TNF-alpha are affected by insulin dose or muscle contraction. Whole body glucose infusion rate (GIR), femoral blood flow (FBF), hindleg vascular resistance, hindleg glucose uptake (HGU), 2-deoxyglucose uptake into muscles of the lower leg (R'g) and hindleg metabolism of infused 1-methylxanthine (1-MX), a measure of capillary recruitment, were determined. Three groups were studied with and without infusion of TNF-alpha: euglycemic insulin-clamped, one-leg field-stimulated (2 Hz, 0.1 ms at 30 V), and saline-infused control anesthetized rats. Insulin infusions were 3, 10, or 30 mU x kg-1 x min-1 for 2 h x 1-MX metabolism was maximally increased by all three doses of insulin. GIR, HGU, and R'g were maximal at 10 mU and FBF was maximal at 30 mU of insulin. Contraction increased FBF, HGU, and 1-MX. TNF-alpha (0.5 microg x kg-1 x h-1) totally blocked the 3 and 10 mU insulin-mediated increases in FBF and 1-MX, and partly blocked GIR, HGU, and R'g. None of the increases due to twitch contraction was aff...Continue Reading

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Citations

Oct 21, 2010·American Journal of Physiology. Endocrinology and Metabolism·Hong WangEugene J Barrett
Oct 28, 2010·American Journal of Physiology. Endocrinology and Metabolism·Nasui WangZhenqi Liu
May 26, 2011·American Journal of Physiology. Endocrinology and Metabolism·Eugene J BarrettZhenqi Liu
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Apr 17, 2013·Reviews in Endocrine & Metabolic Disorders·Tetsuya KubotaTakashi Kadowaki
Mar 5, 2015·Trends in Endocrinology and Metabolism : TEM·Chao Zheng, Zhenqi Liu
Oct 25, 2012·Diabetes·Eugene J Barrett, Stephen Rattigan
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Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Michael G ClarkEugene J Barrett
Mar 29, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bolin QinKhosrow Adeli
Oct 7, 2010·American Journal of Physiology. Endocrinology and Metabolism·Francesca SchinzariCarmine Cardillo
Jul 3, 2020·Biomedicines·Yusuke TakedaRimei Nishimura
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Jan 10, 2013·American Journal of Physiology. Endocrinology and Metabolism·Nasui WangZhenqi Liu
Feb 1, 2019·International Journal of Molecular Sciences·Jia Liu, Zhenqi Liu
Oct 31, 2020·Endocrine Reviews·William B Horton, Eugene J Barrett

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