TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells.

Neurochemical Research
Yongwei QinAiguo Shen

Abstract

In the peripheral nervous system (PNS), tumor necrosis factor-alpha (TNF-alpha) derived from activated Schwann cells (SCs) play a critical role as a pleiotropic mediator. In this study, we examined the function of TNF-alpha as an inflammatory mediator in SCs activation. TNF-alpha exhibits its biological effect through two distinct surface receptors, TNF receptor 1 (TNFR1) and TNFR2. We show here that cultured SCs express both TNFR1 and TNFR2, and that activation of these receptors by TNF-alpha promotes expression of TNF-alpha. Meanwhile, TNF-alpha also increased the production of other inflammatory mediators. Furthermore, TNF-alpha is involved in the induction of apoptosis through binding to TNFR in SCs. The activation of SCs by lipopolysaccharide (LPS) is partially mediated by SCs-derived TNF-alpha. These findings suggest the existence of a positive feedback loop in the activation of SC via TNF-alpha. This loop may be involved in the prolonged activation of SCs. Acute or chronic stimulation of TNF-alpha by SC at sites of PNS inflammation may be critical in determining whether TNF-alpha has activational, inflammatory, or cytotoxic effects on these cells.

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Citations

Jan 18, 2018·Nature Communications·Vadims ParfejevsLukas Sommer
Jan 30, 2010·Cellular and Molecular Neurobiology·Zhengming ZhouXiang Lu
Jul 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Prabhjot S DhadiallaSidney Strickland
Aug 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katherine A MattosPatricia T Bozza
Dec 5, 2012·Journal of Pathogens·Ayssar A ElaminMahavir Singh
Apr 18, 2014·Journal of Clinical Immunology·Nevena TzekovaPatrick Küry
Jan 6, 2012·Neurochemical Research·Yongwei QinChun Cheng
Jun 26, 2009·Journal of Neurophysiology·Akhlaq W HakimBrian E Cairns
Oct 16, 2020·Molecular Pain·Jia-Yi LiaoZeng-Xu Liu

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