PMID: 7544768Feb 1, 1995Paper

TNF alpha blockade in rheumatoid arthritis: rationale, clinical outcomes and mechanisms of action

International Journal of Immunopharmacology
M J ElliottR N Maini

Abstract

Tumor necrosis factor alpha (TNF alpha) is a cytokine with many biological functions of relevance to inflammatory disease. Although only one of several inflammatory mediators produced in abundance in rheumatoid arthritis (RA), experimental data suggest that it is in a dominant position within a cytokine hierarchy and is therefore a prime target for directed immunotherapy in this disease. We have targeted TNF alpha in vivo using a chimerised monoclonal anti-TNF alpha antibody and have now demonstrated beneficial responses to treatment in three different clinical trials. The results confirm that TNF alpha is of central importance in the inflammatory process in RA and define a new treatment strategy in this disease.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R O WilliamsR N Maini
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·R O WilliamsR N Maini
Jan 30, 1993·Lancet·P M Brooks
Jan 1, 1994·International Archives of Allergy and Immunology·M J Elliott, R N Maini

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Jan 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Weiyuan John KaoKelly Stevens
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