TNF-alpha converting enzyme (TACE) protein expression in different clinical subtypes of multiple sclerosis

Journal of Neurology
Manuel ComabellaXavier Montalban

Abstract

Tumor necrosis factor (TNF)-alpha converting enzyme (TACE, also called ADAM17) is a key sheddase that releases TNF-alpha from its inactive cell-bound precursor. TACE protein expression levels in peripheral blood mononuclear cells were measured by Western blot analysis in 20 healthy controls and 80 multiple sclerosis (MS) patients before and after treatment with IFNbeta [20 patients with primary progressive (PP) MS, 20 patients with secondary progressive (SP) MS, and 40 patients with relapsing- remitting (RR) MS (20 patients during clinical remission and 20 patients in relapse)]. TNF-alpha serum levels were also measured by enzyme-linked immunoassay in the MS patients and healthy controls. TACE protein expression levels were lower in healthy controls and PPMS patients compared with SPMS patients and RRMS patient during clinical remission. No differences in TACE protein levels were observed between RRMS patients in relapse and during remission. TACE protein levels were increased in PPMS patients treated with IFNbeta. Serum TNF-alpha levels were higher in RRMS patients in relapse compared with RRMS patients during remission, and positive and negative correlations were found between TACE protein expression and serum TNF-alpha level...Continue Reading

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Citations

Jul 25, 2012·Indian Journal of Ophthalmology·Renu Agarwal, Puneet Agarwal
Mar 9, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Dmitri BezinoverPiotr K Janicki
Jan 29, 2011·Archives of Physical Medicine and Rehabilitation·Diego Munguía-IzquierdoKaisa Mannerkorpi
Aug 31, 2014·Immunology Letters·Sabrina LisiMargherita Sisto
Feb 27, 2010·Critical Reviews in Biochemistry and Molecular Biology·Monika Gooz
Dec 1, 2012·The Journal of Pharmacology and Experimental Therapeutics·Ji-Yeon ChoiJihee Lee Kang
Oct 18, 2020·Cells·Diego FresegnaAntonietta Gentile

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