TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility

The Oncologist
Remco van HorssenAlexander M M Eggermont

Abstract

Tumor necrosis factor alpha (TNF-alpha), isolated 30 years ago, is a multifunctional cytokine playing a key role in apoptosis and cell survival as well as in inflammation and immunity. Although named for its antitumor properties, TNF has been implicated in a wide spectrum of other diseases. The current use of TNF in cancer is in the regional treatment of locally advanced soft tissue sarcomas and metastatic melanomas and other irresectable tumors of any histology to avoid amputation of the limb. It has been demonstrated in the isolated limb perfusion setting that TNF-alpha acts synergistically with cytostatic drugs. The interaction of TNF-alpha with TNF receptor 1 and receptor 2 (TNFR-1, TNFR-2) activates several signal transduction pathways, leading to the diverse functions of TNF-alpha. The signaling molecules of TNFR-1 have been elucidated quite well, but regulation of the signaling remains unclear. Besides these molecular insights, laboratory experiments in the past decade have shed light upon TNF-alpha action during tumor treatment. Besides extravasation of erythrocytes and lymphocytes, leading to hemorrhagic necrosis, TNF-alpha targets the tumor-associated vasculature (TAV) by inducing hyperpermeability and destruction of ...Continue Reading

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
May 1, 1992·Immunology Today·L A Tartaglia, D V Goeddel
Jan 1, 1992·Clinical Immunology and Immunopathology·C E SpoonerL D Saravolatz
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D LienardF J Lejeune
Nov 8, 1985·Science·L J Old
Jan 1, 1988·Immunopharmacology and Immunotoxicology·N WatanabeI Urushizaki
Feb 15, 1988·International Journal of Cancer. Journal International Du Cancer·K ShimomuraJ Mori
Sep 15, 1988·International Journal of Cancer. Journal International Du Cancer·E KnippelA Krygier-Stojalowska
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Aug 1, 1993·The British Journal of Surgery·S HillJ M Thomas
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F J LejeuneR O Mirimanoff
Jun 19, 1993·International Journal of Cancer. Journal International Du Cancer·P L NarediL R Hafström
Apr 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E R ManusamaA M Eggermont
Jun 27, 1996·The New England Journal of Medicine·F Bazzoni, B Beutler
Jan 1, 1996·Critical Reviews in Immunology·M H BemelmansW A Buurman
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A M EggermontF J Lejeune
Jul 1, 1997·Trends in Biochemical Sciences·F BussolinoG Persico
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Oct 31, 1998·Current Opinion in Immunology·F J LejeuneD Liénard
Jan 23, 1999·Oncogene·S J Baker, E P Reddy
May 1, 1999·The Journal of Biological Chemistry·K Y LeeG D Rosen
Jan 14, 2000·Journal of Clinical Immunology·P C Rath, B B Aggarwal
Apr 7, 2000·The American Journal of Pathology·H HashizumeD M McDonald
Aug 24, 2000·International Journal of Cancer. Journal International Du Cancer·T L Ten HagenA M Eggermont

❮ Previous
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Citations

Mar 30, 2011·Archives of Toxicology·Evandro Fei FangTzi Bun Ng
Jan 31, 2013·Analytical and Bioanalytical Chemistry·Betul BilginS Patrick Walton
Aug 8, 2007·Journal of Cancer Research and Clinical Oncology·Bo ZhangBo Yang
Jan 20, 2011·Clinical and Experimental Medicine·Tomomitsu TaharaTomiyasu Arisawa
Feb 13, 2009·Apoptosis : an International Journal on Programmed Cell Death·Han-Ming Shen, Vinay Tergaonkar
Oct 6, 2009·Breast Cancer Research and Treatment·Michael S SabelAlfred E Chang
Mar 12, 2009·Medical Oncology·Inès ZidiNidhal Ben Amor
Jul 12, 2011·Acta Pharmacologica Sinica·Zhao-Zhin Joanna LimBoon-Huat Bay
Sep 3, 2010·Nature Reviews. Drug Discovery·Manfred KopfBenjamin J Marsland
Apr 7, 2012·Nanoscale·De-Hao TsaiVincent A Hackley
Sep 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Qian ZhangMariusz A Wasik
Oct 2, 2013·The Journal of Experimental Medicine·Myriam N BouchlakaWilliam J Murphy
Sep 8, 2007·Antioxidants & Redox Signaling·Alicja JozkowiczJozef Dulak
Mar 9, 2013·Inflammatory Bowel Diseases·Mysha Mason, Corey A Siegel
Oct 27, 2006·Journal of Virology·John W BarrettGrant McFadden
May 23, 2007·Molekuliarnaia biologiia·S A Nedospasov, D V Kuprash
Jul 31, 2012·Annals of the Rheumatic Diseases·Sarah E WytheCostantino Pitzalis
Nov 16, 2012·Cancer Research·Guang-Hui WangXiao-Kun Zhang
Sep 30, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven K LibuttiLawrence Tamarkin
Aug 30, 2008·Molecular Cancer Therapeutics·Jing JiangJohn C Bischof
May 2, 2012·BMC Bioinformatics·Corban G RiveraT M Murali
Aug 31, 2013·Molecular Cancer·Rudi BeyaertFilip De Keyser
Nov 10, 2013·Cell Communication and Signaling : CCS·Kentaro HayashiKumar Selvarajoo
May 9, 2012·PloS One·Kun YangRonald J Buckanovich
Apr 20, 2013·Nutrients·Georgia Lenihan-GeelsLynnette R Ferguson
Aug 13, 2014·International Journal of Nanomedicine·Tanja SchaffranDetlef Gabel
May 6, 2011·Nanomedicine·Mithun M ShenoiJohn C Bischof
May 6, 2014·Protein Engineering, Design & Selection : PEDS·Christian Hess, Dario Neri
Dec 5, 2013·Endocrine-related Cancer·Lucas Leite CunhaLaura Sterian Ward
Jun 20, 2014·International Journal of Biological Macromolecules·Fanli KongHaibin Tong
May 13, 2014·Digestive Diseases and Sciences·Alexis A RodriguezGerald J Berry

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