PMID: 9184649Jun 1, 1997Paper

TNF alpha in cerebrospinal fluid of meningitis patients reduces astrocytes membrane potential

Journal of Neuroimmunology
H Köller

Abstract

During inflammatory CNS diseases cytokines are released into the cerebrospinal fluid (CSF). Astrocytes which are target cells for cytokines also contribute importantly to undisturbed neuronal function e.g. by maintaining local ion homeostasis. The effects of CSF from patients with septic (CSF-SM) and aseptic (CSF-ASM) meningitis on electrophysiological membrane properties of cultured rat cortical astrocytes were investigated. Astrocytes significantly depolarized from a membrane potential of -75.6 +/- 2.3 to -47.4 +/- 6.2 mV in CSF-SM (n = 8). 12 of 18 CSF-ASM also induced a depolarization. The depolarization of astrocytes was inhibited by a neutralizing anti-TNF alpha antibody, indicating that the cytokine TNF alpha initiates the depolarization.

References

Apr 1, 1991·The Journal of Infectious Diseases·B MøllerC M Petersen
Dec 13, 1990·The New England Journal of Medicine·S L PomeroyR D Feigin
Dec 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·M Anderson
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Aug 15, 1991·Physical Review. B, Condensed Matter·W R Lambrecht van Schilfgaarde M

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Citations

Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Krishnan Sriram, James P O'Callaghan
Dec 2, 2000·Neurochemistry International·R C ChangD Tsang
Oct 30, 2007·Archives of Physical Medicine and Rehabilitation·Andrew L DaviesGregory A Dekaban
Apr 9, 2010·The European Journal of Neuroscience·Antje DiestelKatharina R L Schmitt

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