TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated

Brain Research Bulletin
M FleshnerS F Maier

Abstract

Immune activation leads to production of mediators such as cytokines, which act to induce both brain-mediated and peripheral defense processes. We used intraperitoneal administration of the cytokine tumor necrosis factor-alpha (TNF-alpha) to investigate whether defense processes induced by this cytokine are mediated by vagal afferents and/or interleukin-1 (IL-1) receptors. Because some effects of TNF-alpha are mediated, at least in part, by the brain [plasma corticosterone (CORT) elevation] and some are mediated by peripheral organs [reduction of serum protein and corticosteroid binding globulin (CBG)], we also investigated whether the effects of vagotomy are specific to those defense processes mediated by the brain. Both vagotomy and IL-1 receptor antagonist attenuated serum CORT elevation, but had no effects on serum protein or CBG reduction. These results support the idea that vagal afferents provide a true immune-to-brain pathway that may include IL-1 receptors.

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Citations

Jan 15, 2014·Cytokine & Growth Factor Reviews·Lien DejagerClaude Libert
Mar 1, 1997·Journal of Neuroimmunology·B Safieh-GarabedianN E Saadé
May 12, 2010·Cytokine & Growth Factor Reviews·Tom Van BogaertClaude Libert
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Mar 1, 2001·Stress : the International Journal on the Biology of Stress·C Rivier
Feb 9, 2017·Stress : the International Journal on the Biology of Stress·Marni Anne NenkeDavid James Torpy
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Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A P KohmS B Jones3
Jul 31, 2018·Expert Review of Endocrinology & Metabolism·Emily J MeyerDavid J Torpy

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