PMID: 9542779May 30, 1998Paper

TNF-alpha induces the transcription factor Egr-1, pro-inflammatory cytokines and cell proliferation in human skin fibroblasts and synovial lining cells

Rheumatology International
B GrimbacherH Eibel

Abstract

In rheumatoid arthritis (RA) cell proliferation and altered metalloproteinase expression of synovial lining cells are associated with increased levels of TNF-alpha in the rheumatoid joint. We previously showed that synoviocytes of RA patients express high levels of the transcription factor Egr-1. Here we report that TNF-alpha is capable of inducing high Egr-1 mRNA levels in human skin fibroblasts and in synoviocytes from both, RA and reactive arthritis patients. Moreover, we observed in vitro a marked increase in fibroblast proliferation, a loss of growth inhibition by cell-to-cell contact with pannus-like cell growth and an altered cytokine expression pattern when synoviocytes were cultured in presence of TNF-alpha.

Citations

Dec 23, 2003·Immunology Letters·Sung-Jin HuhJeehee Youn
Mar 6, 2007·Nature Clinical Practice. Rheumatology·Philipp DreesLars C Huber
May 18, 1999·Current Opinion in Rheumatology·U Müller-LadnerS Gay
Oct 18, 2012·Arthritis Research & Therapy·Athanassios FragoulisChristoph Jan Wruck
Jan 17, 2012·International Journal of Molecular Medicine·Elke KunischRaimund W Kinne
Jun 2, 2007·Pathology, Research and Practice·Akira KidoYoshinori Takakura
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kouji TsugawaAndrzej S Tarnawski
Nov 13, 2018·Molecular Biology Reports·JuHwan KimSoon Young Shin
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas DryndaThomas Pap
Oct 16, 2020·International Journal of Molecular Sciences·Dong Yeong MinSoon Young Shin
Feb 4, 2019·Biochemical and Biophysical Research Communications·Fernando S SantiagoLevon M Khachigian
Sep 4, 2021·Journal of the American Heart Association·Fernando S SantiagoLevon M Khachigian

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