TNF-alpha receptor 1 deficiency enhances kainic acid-induced hippocampal injury in mice

Journal of Neuroscience Research
Ming-Ou LuAbdu Adem

Abstract

The exact role of TNF-alpha in excitotoxic neurodegeneration of the brain is unclear. To address this issue, the kainic acid (KA)-induced hippocampal injury model, a well-characterized model of human neurodegenerative diseases, was used in TNF-alpha receptor 1 (TNFR1)-knockout (TNFR1-/-) mice in the present study. After nasal application of a single dose of 40 mg of KA per kilogram body weight, TNFR1-/- mice showed significantly more severe seizures than the wild-type mice. In addition, obvious neurodegeneration, enhanced microglia activation, and astrogliosis in the hippocampus, as well as increased locomotor activity, were found in TNFR1-/- mice compared with the wild-type controls 8 days after KA delivery. Moreover, CC chemokine receptor 3 expression on activated microglia was increased 3 days after KA treatment in TNFR1-/- mice, as measured by flow cytometry. These data suggest that TNF-alpha may play a protective role through TNFR1 signaling.

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Citations

Nov 26, 2010·Journal of Neurology·Ming-Ou Lu, Jie Zhu
Dec 4, 2010·Journal of Biomedicine & Biotechnology·Xiang-Yu ZhengJie Zhu
Jan 23, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Nur Shafika Mohd SairaziSiti Amrah Sulaiman
Apr 13, 2010·Neurobiology of Disease·Martine M MirrioneStella E Tsirka
May 23, 2008·Brain, Behavior, and Immunity·Annamaria VezzaniTeresa Ravizza
Dec 4, 2019·Neuropsychopharmacology Reports·Tasuku ArakiRyuta Koyama
Aug 16, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Nur Shafika Mohd SairaziSiti Amrah Sulaiman

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