TNF alpha signaling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors

Molecular and Cellular Endocrinology
Constanze HantelFelix Beuschlein

Abstract

ASA404 (Vadimezan) belongs to a class of agents with disrupting properties against tumor vasculature, which is partly mediated by TNFα-signaling. Preclinical and early clinical studies have indicated promising results for ASA404, while extended clinical trials performed poorly. Our aim was to investigate the potential therapeutic applicability of ASA404 against endocrine tumors. Moreover, as the reason for the unpredictable clinical anti-tumor activity of ASA 404 remained uncertain in previous studies, we compared two tumor models of endocrine origin with different responses to ASA404 treatment. Specifically, we determined anti-tumoral effects in preclinical models of neuroendocrine tumors of the gastroenteropancreatic system (BON) and adrenocortical cancer (NCI-H295R) in vitro and in xenograft models in vivo. Upon treatment of tumor bearing mice significant anti-tumoral effects, an increase in TNFα as well as activation of TNFα-specific downstream signaling were evident in the BON tumor model while no comparable effects were detectable for NCI-H295R. We identified TNFAIP3/A20, a key molecule of an inhibitory feedback-loop downstream of TNF-receptor 1, CD40, Toll-like receptors, NOD-like receptors and the interleukin-1 receptor...Continue Reading

References

Dec 29, 1998·Cell·M D Jacobs, S C Harrison
Mar 8, 2003·The Lancet Oncology·Bruce C Baguley
Jan 18, 2005·Journal of Cell Science·Inna LavrikPeter H Krammer
Jun 2, 2005·Nature Reviews. Cancer·Gillian M TozerBruce C Baguley
Mar 27, 2007·European Journal of Pharmacology·Ricardo P GarayCarlo Chiavaroli
Dec 22, 2007·Expert Opinion on Investigational Drugs·Mark J McKeage
Jan 8, 2008·The Lancet Oncology·Irvin M ModlinAnders Sundin
Apr 29, 2008·Nature Immunology·Tatsukata KawagoeShizuo Akira
May 21, 2008·Nature Immunology·Etienne Meylan, Jürg Tschopp
Sep 24, 2008·Expert Opinion on Investigational Drugs·Farah Rehman, Gordon Rustin
Nov 15, 2008·The Journal of Biological Chemistry·Beatrice CoornaertRudi Beyaert
May 5, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mark J McKeageJoachim Von Pawel
Mar 13, 2012·The Journal of Endocrinology·Constanze HantelFelix Beuschlein
May 1, 2012·Cytokine & Growth Factor Reviews·Vincent P RamirezBrian J Aneskievich
Oct 13, 2012·Nature Reviews. Immunology·Averil Ma, Barbara A Malynn
Feb 9, 2013·Cytokine & Growth Factor Reviews·Aleksandra M DudekPatrizia Agostinis
Sep 28, 2013·Oncoimmunology·Ming LiTrina J Stewart
Oct 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Martin FassnachtBruno Allolio
Nov 20, 2013·Trends in Immunology·Leen CatrysseGeert van Loo
Jan 16, 2014·Endocrine Reviews·Tobias ElseGary D Hammer
Apr 10, 2014·Advances in Anatomic Pathology·Lori A EricksonJun Zhang
Apr 22, 2014·Nature Genetics·Guillaume AssiéJérôme Bertherat
May 24, 2014·Journal for Immunotherapy of Cancer·David A SchaerJedd D Wolchok
Jul 6, 2015·Cancer Treatment Reviews·Chiara Alessandra CellaNicola Fazio

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Citations

Apr 1, 2008·Methods in Enzymology·Masahiko OkaIvan F McMurtry
Apr 13, 2019·Endocrine Connections·Sofia S PereiraDuarte Pignatelli
Aug 6, 2019·Frontiers in Endocrinology·Claudia SiebertFelix Beuschlein
Dec 31, 2019·Endocrinology and Metabolism·Sergei G TevosianHans K Ghayee
May 3, 2021·Cancer Letters·Yongyu ShiLining Zhang
Nov 2, 2020·European Journal of Pharmacology·Ryszard SmolarczykTomasz Cichoń

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