TNF-alpha tolerance blocks LPS-induced hypophagia but LPS tolerance fails to prevent TNF-alpha-induced hypophagia

The American Journal of Physiology
M H PorterW Langhans

Abstract

To investigate the role of tumor necrosis factor-alpha (TNF-alpha) in bacterial lipopolysaccharide (LPS)-induced hypophagia, we tested whether a cross tolerance between LPS and TNF-alpha exists with respect to their anorectic effects. Only the first of three subsequent intraperitoneal injections of LPS (100 micrograms/kg body wt) given every second day at dark onset (12:12-h light-dark cycle) led to a significant reduction of food intake in male rats. Likewise, intraperitoneal injections of human recombinant TNF-alpha (150 micrograms > or = 3 x 10(6) U/kg body wt) also resulted in tolerance to its hypophagic effect. LPS tolerance did not alter the hypophagic response to subsequently injected TNF-alpha (n = 14). However, TNF-alpha pretreatment completely blocked the hypophagic response to LPS (n = 14). The results demonstrate that tolerance to the hypophagic effect of exogenous TNF-alpha is sufficient to eliminate LPS-induced hypophagia. This is consistent with the hypothesis that endogenous TNF-alpha plays a major role in LPS-induced hypophagia. The ineffectiveness of LPS tolerance to attenuate TNF-alpha-induced hypophagia is compatible with findings demonstrating that reduced TNF-alpha production is an important feature of LPS...Continue Reading

References

Mar 1, 1979·The American Journal of Clinical Nutrition·M J Murray, A B Murray
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·C R Plata-Salamán
Jul 1, 1988·The Journal of Experimental Medicine·D L FrakerJ A Norton
Jun 1, 1988·The Journal of Experimental Medicine·S H SocherD Martinez
Feb 1, 1987·The Journal of Clinical Investigation·C F Nathan
Jul 1, 1994·The Journal of Surgical Research·M H LiM A West
Jul 1, 1995·Immunobiology·H W Ziegler-HeitbrockA Wedel
Jun 13, 1996·Biochimica Et Biophysica Acta·M MakhloufJ A Cook
Mar 1, 1996·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·D AltavillaA P Caputi
Jun 30, 1947·The Journal of Experimental Medicine·P B Beeson, UNKNOWN Technical Assistance of Elizabeth Roberts

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Citations

Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M H PorterW Langhans
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Paulette M JohnsonLouis J Muglia
Jun 28, 2012·The Journal of Physiological Sciences : JPS·Morteza ZendehdelElham Amini

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