TNF as a Target of Inflammation in Rheumatoid Arthritis

Endocrine, Metabolic & Immune Disorders Drug Targets
Hisashi Yamanaka

Abstract

Anti-Tumor Necrosis Factor (TNF) agents were the first molecular targeting drugs developed for the treatment of rheumatoid arthritis (RA). Anti-TNF agents improve the clinical picture of severe RA patients, inhibit joint destruction and improve quality of life. In the 15 years since their introduction, they have become the preferred drug therapy for management of RA. The success of anti-TNF agents in the treatment of RA has resulted in the development of many drugs for other inflammatory diseases using the same molecular targeting concept. However, many unresolved issues surround the use of anti-TNF agents, including the risk for infection, primary non-responders, secondary loss of efficacy and pharmacoeconomical issues. This review focuses on the multifaceted impact of anti-TNF agents in the treatment of RA.

Citations

Sep 19, 2015·Molecular Nutrition & Food Research·María Angeles RosilloCatalina Alarcón-de-la-Lastra
May 20, 2015·Autoimmunity Reviews·Guo-Cui WuDong-Qing Ye
May 18, 2016·Arthritis Research & Therapy·Huan ShiChuangqi Yu
Mar 24, 2017·Journal of Cutaneous Pathology·Olga K AfanasievSteven M Ruhoy
Jan 13, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Chao HanWanyu Shi
Nov 28, 2018·Journal of Biomedical Materials Research. Part a·Fei XuHong Zheng
Sep 14, 2017·Natural Product Research·Nguyen Quoc VuongNguyen Tien Dat
Jan 23, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Olfat G ShakerEnas M Hefzy
Jun 13, 2019·The Journal of Experimental Medicine·David E Place, Thirumala-Devi Kanneganti
Jun 20, 2018·Frontiers in Endocrinology·Satish K Raut, Madhu Khullar
Feb 12, 2019·Bioelectronics in Medicine·Alexandre KanashiroLuis Ulloa
Jun 11, 2019·Frontiers in Immunology·Wen-Tao MaDe-Kun Chen
Apr 16, 2019·ACS Chemical Neuroscience·Andrea CruzInês Mendes Pinto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here