TNF Block Gene Variants Associate With Pain Intensity in Black Southern Africans With HIV-associated Sensory Neuropathy

The Clinical Journal of Pain
Liesl M HendryPeter R Kamerman

Abstract

HIV-associated sensory neuropathy (HIV-SN) is a common neurological complication of HIV infection, and it is often painful. Tumor necrosis factor (TNF)-α is implicated in neuropathic pain, but associations between neuropathic pain and polymorphisms in the TNFA gene have not been identified. The "TNF block" is a region of high linkage disequilibrium within the central major histocompatability complex that contains several genes involved in the regulation of inflammation, including TNFA. Polymorphisms in the block have been associated with an altered risk of HIV-SN, but no investigations into whether this region is associated with the painful symptoms of neuropathy have been undertaken. Therefore, we investigated whether polymorphisms in the TNF block are associated with pain intensity in black Southern Africans with HIV-SN. Single-nucleotide polymorphisms (SNPs) defining TNF block haplotypes and African-specific tagSNPs were genotyped in samples from 150 black Southern Africans with HIV-SN. One SNP allele, rs28445017*A, was significantly associated with an increased pain intensity after correction for age, sex, and the CD4 T-cell count. A common 3-SNP haplotype containing rs28445017*G remained associated with a reduced pain inte...Continue Reading

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Citations

Dec 15, 2017·Pain·Katerina Zorina-LichtenwalterLuda Diatchenko
Jun 1, 2017·Journal of Neurovirology·Huguette Gaelle Ngassa MbendaPeter Kamerman
Nov 24, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Thomas JulianPanagiotis Zis
Jan 21, 2021·International Journal of Molecular Sciences·Dario KringelJörn Lötsch
Oct 23, 2020·Pain·Blair H SmithAbirami Veluchamy
Jun 26, 2020·Journal of the Neurological Sciences·Jessica GaffPeter Kamerman
Aug 15, 2021·Journal of Diabetes and Its Complications·Panoraia BakaFrank Birklein

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Methods Mentioned

BETA
Assay
genotyping

Software Mentioned

Haploview
Ensembl
ACTG Brief
BeadStudio
PLINK
BioMart
Illumina Assay Design Tool

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