TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

Nature Medicine
J LiuC C Bernard

Abstract

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) characterized by localized areas of demyelination. Although the etiology and pathogenesis of MS remain largely unknown, it is generally assumed that immune responses to myelin antigens contribute to the disease process. The exact sequence of events, as well as the molecular mediators that lead to myelin destruction, is yet to be defined. As a potent mediator of inflammation, the cytopathic cytokine, tumor necrosis factor (TNF) has been considered to be a strong candidate in the pathogenesis of MS and its animal model, experimental autoimmune encephalomyelitis (EAE). However, its role in immune-mediated demyelination remains to be elucidated. To determine the contribution of TNF to the pathogenesis of the MS-like disease provoked by the myelin oligodendrocyte glycoprotein (MOG), we have tested mice with an homologous disruption of the gene encoding TNF. Here we report that upon immunization with MOG, mice lacking TNF develop severe neurological impairment with high mortality and extensive inflammation and demyelination. We show further that inactivation of the TNF gene converts MOG-resistant mice to a state of high susceptibility. Furthermore,...Continue Reading

References

Oct 1, 1992·Current Opinion in Cell Biology·C P Blobel, J M White
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M LewisD V Goeddel
Aug 15, 1991·The New England Journal of Medicine·M K Sharief, R Hentges
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C O JacobH Acha-Orbea
Jan 28, 1988·Nature·C O Jacob, H O McDevitt
Jan 1, 1993·Annual Review of Immunology·E E SercarzK Moudgil
Jul 1, 1996·Nature Medicine·N J Rothwell, G N Luheshi
Aug 1, 1996·Trends in Neurosciences·J E Merrill, E N Benveniste
Aug 15, 1996·Journal of Neuroscience Research·V Navikas, H Link
Feb 1, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·C C BernardJ Bettadapura
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·M W MarinoL J Old

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Citations

Feb 16, 2000·Biochemical and Biophysical Research Communications·Y OkudaT Yanagihara
Jul 31, 1998·Clinical Immunology and Immunopathology·B M Segal, E M Shevach
Jul 31, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ewa KozelaZvi Vogel
Mar 20, 2012·Clinical Reviews in Allergy & Immunology·Anupam MitraHermenio Cavalcante Lima
Jan 31, 2009·Journal of Biosciences·Dipankae Nandi, Manoj Bhosale
Jul 16, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hiroyuki FukazawaSeiitsu Ono
Jun 2, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Ling WeiShan Ping Yu
May 18, 2000·Journal of Neuroimmunology·Y KitamuraP J Gebicke-Haerter
Dec 8, 2000·Journal of Neuroimmunology·A H CrossJ Lyons
Aug 6, 2002·Journal of Neuroimmunology·Kenichi SakuraiGene M Shearer
Jan 1, 2003·Journal of Neuroimmunology·Harald H HofstetterZsuzsa Fabry
Apr 27, 2000·Immunology Today·H DrakesmithP Beverley
Nov 18, 1998·Immunology Today·J D LamanL Kappos
Apr 22, 1999·Immunology Today·J Borst, A Cope
Jul 23, 2003·Neuroscience Research·Shin HisaharaMasayuki Miura
Feb 25, 2000·Brain Research. Molecular Brain Research·C R Plata-SalamánD C McIntyre
Mar 10, 2001·Progress in Neurobiology·R KieferH P Hartung
Jul 20, 2002·Progress in Neurobiology·Chen Xu Wang, Ashfaq Shuaib
May 26, 1999·Progress in Neurobiology·G Stoll, S Jander
Jan 29, 1999·Research in Immunology·T OwensM Krakowski
Sep 7, 2001·Current Opinion in Immunology·L Steinman
Jan 23, 1999·Current Opinion in Immunology·A P Cope
Jan 23, 1999·Current Opinion in Immunology·S Sawcer, P N Goodfellow

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