TNF promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning

International Journal of Chronic Obstructive Pulmonary Disease
Juan M Reséndiz-HernándezRamcés Falfán-Valencia

Abstract

Smoking and smoke from biomass burning (BB) are the main environmental risk factors for COPD. Clinical differences have been described between COPD related to smoking and related to wood smoke, but no studies have shown genetic differences between patients exposed to these two risk factors. To investigate a possible association of tumor necrosis factor (TNF) promoter polymorphisms, we conducted a case-control study. A total of 1,322 subjects were included in four groups: patients with a diagnosis of COPD secondary to smoking (COPD-S, n=384), patients with COPD secondary to biomass burning (COPD-BB, n=168), smokers without COPD (SWOC, n=674), and biomass burning-exposed subjects (BBES n=96). Additionally, a group of 950 Mexican mestizos (MMs) was included as a population control. Three single nucleotide polymorphisms (SNPs) were selected in the TNF gene (rs1800629, rs361525, and rs1800750) and one SNP in the lymphotoxin alpha gene (rs909253). Statistically significant differences were found with genotype GA of the rs1800629: COPD-S vs SWOC, (p<0.001, odds ratio [OR] =2.55, 95% CI=1.53-4.27); COPD-S vs COPD-BB (p,0.01). When performing the comparison of the less severe (G1: I + II) and the more severe (G2: III + IV) levels, diffe...Continue Reading

Citations

Jan 2, 2020·International Journal of Molecular Sciences·Marco Antonio Ponce-GallegosRamcés Falfán-Valencia
Aug 28, 2021·International Journal of Molecular Sciences·Yadira PalaciosLeslie Chavez-Galan
Mar 31, 2020·Respiration; International Review of Thoracic Diseases·H Dean Hosgood IiiJordi Olloquequi

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Haploview
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SPSS
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