TNF receptor I polymorphism is associated with persistent palindromic rheumatism

Scandinavian Journal of Rheumatology
L-Y LuP-K Sung

Abstract

To investigate the association between tumour necrosis factor-alpha (TNFalpha), TNF receptor superfamily member 1A (TNFRSF1A, also known as TNFRI), TNFRSF1B (TNFRII), and interleukin-1beta (IL-1beta) single nucleotide polymorphisms (SNPs) and the susceptibility to persistent palindromic rheumatism (PR). Fifty-six unrelated patients with persistent PR and 100 unrelated healthy controls were genotyped for TNFalpha -308G/A, -238G/A, and +488G/A, TNFRSF1A -609G/T and +36A/G, TNFRSF1B +676T/G and +1663G/A, and IL-1beta -511C/T, -31T/C, and +3954C/T using real-time polymerase chain reaction (RT-PCR). The TNFRSF1A +36G allele [odds ratio (OR) = 3.94, p = 0.003, corrected p (p(c)) = 0.03] and the TNFRSF1A +36AG genotype (OR = 4.81, p = 0.002, p(c) = 0.04) were significantly associated with persistent PR. The frequency of TNFRSF1B +676T/+1663A was increased in PR patients (OR = 2.12, p = 0.01), but failed to reach statistical significance after Bonferroni correction. No correlation was observed between persistent PR and TNFalpha, TNFRSF1A -609G/T, or IL-1beta SNPs. The results of this study provide evidence of an association between persistent PR and SNPs within the TNFRSF1A gene, and suggest that TNFRI is involved in the aetiopathogene...Continue Reading

References

Feb 1, 1977·Annals of the Rheumatic Diseases·M A WajedH L Currey
Oct 1, 1992·The American Journal of Medicine·P A Guerne, M H Weisman
Jan 1, 1987·Scandinavian Journal of Rheumatology·P HannonenM Oka
Nov 1, 1986·British Journal of Rheumatology·L R FisherM Shipley
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A G WilsonG W Duff
Jul 19, 2000·Current Opinion in Immunology·J GalonD L Kastner
Jul 13, 2002·Arthritis and Rheumatism·Stéphane GenevayPierre-André Guerne
Sep 5, 2002·Arthritis and Rheumatism·Catherine DodéUNKNOWN French Heraditary Recurrent Inflammatory Disorder Study Group
Oct 1, 1995·Trends in Cell Biology·P VandenabeeleW Fiers
Feb 12, 2004·Arthritis and Rheumatism·Philippe DieudéUNKNOWN European Consortium on Rheumatoid Arthritis Families
Mar 17, 2004·BMC Genetics·Bianca MiterskiJörg Thomas Epplen
Sep 30, 2004·Best Practice & Research. Clinical Rheumatology·Raimon SanmartiGeorgina Salvador
Nov 5, 2004·Genes and Immunity·L B HughesS L Bridges

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Citations

May 11, 2010·Molecular and Cellular Probes·Sabine Hoffjan, Denis A Akkad
Mar 6, 2021·Expert Review of Clinical Immunology·Raimon SanmartíJuan D Cañete
Apr 13, 2021·Frontiers in Medicine·Raimon SanmartíJuan D Cañete

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