TNF receptor independent activation of the cytomegalovirus major immediate early enhancer in response to transplantation.

Transplantation
Zheng ZhangMichael Abecassis

Abstract

Reactivation of latent human cytomegalovirus (HCMV) infection is a significant risk factor for long term allograft dysfunction. The molecular pathways involved in reactivation of latent virus have not been identified. Previous studies suggested that tumor necrosis factor (TNF) -mediated activation of nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-kappa B) leading to transcriptional reactivation of viral immediate early (ie) gene expression might be important in transplant-associated viral reactivation. CMV IE gene expression is controlled by the major immediate early promoter/enhancer (MIEP). Because HCMV does not infect mice, transgenic mice carrying a beta-galactosidase reporter gene under the control of the HCMV immediate early enhancer (MIEP-lacZ mice) are a valuable model for studying regulation of CMV IE gene expression in vivo. We have used TNF receptor-deficient MIEP-lacZ (MIEP-lacZ TNFR DKO) mice to study the requirement for TNF in transplant-induced activation of the MIEP. Allogenic kidney transplants were performed using MIEP-lacZ TNFR DKO or MIEP-lacZ TNFRwild-type donor mice. beta-Galactosidase activity was used to measure activation of the IE enhancer in donor kidneys at 2 days of posttrans...Continue Reading

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Citations

Jun 21, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kristel De KeyzerRaymond Vanholder
Nov 29, 2014·Epigenomics·Amit Kumar, Georges Herbein
Apr 5, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Zheng ZhangMichael M Abecassis
Jan 31, 2020·Transplantation·Taylor A Heald-SargentMary A Hummel
Apr 17, 2020·Frontiers in Cellular and Infection Microbiology·Eleonora ForteMary Hummel

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