TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation from monocyte/macrophage lineage precursor cells

Molecular Immunology
Men-Luh YenPing-Ning Hsu

Abstract

Human osteoclast formation from mononuclear phagocyte precursors involves interactions between tumor necrosis factor (TNF) ligand superfamily members and their receptors. Many of the proinflammatory cytokines and growth factors implicated in inflammatory processes have also been demonstrated to impact osteoclast differentiation and function. Recent evidence indicates that the TNF-related apoptosis-inducing ligand (TRAIL) of the TNF ligand superfamily, which was initially thought to induce apoptosis in many transformed cell lines, can serve as an effector molecule in activated T cells. We show in this work that TRAIL can induce osteoclast formation from human monocytes and murine RAW264.7 macrophages. We demonstrated that both cell models differentiate into osteoclast-like cells in the presence of TRAIL in a dose-dependent manner, as evaluated in terms of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells and bone resorption activity. The TRAIL-induced osteoclast differentiation is independent of caspase activation and apoptosis induction activity. However, TRAIL-induced osteoclastogenesis is dependent on activation of NF-kappaB, ERK, and p38 MAP kinase. Thus, our data demonstrate that TRAIL induces osteocl...Continue Reading

Citations

Jan 5, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Wai W CheungRobert H Mak
Apr 29, 2015·International Immunopharmacology·Marcelo Henrique NapimogaElizabeth Ferreira Martinez
Jan 21, 2011·The Journal of Investigative Dermatology·Nan-Lin WuWan-Wan Lin
Nov 20, 2016·The FEBS Journal·Daniela SiegmundHarald Wajant
Aug 14, 2020·International Journal of Molecular Sciences·Joe Kodama, Takashi Kaito
Nov 21, 2020·The FEBS Journal·Ludmila Cardoso AlvesPhilippe Krebs

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