Abstract
Numerous studies have implicated tumor necrosis factor α (TNFα) in the pathogenesis of type 2 diabetes. However, the role of its primary receptor, TNF receptor 1 (TNFR1), in homeostatic regulation of glucose metabolism is still controversial. In addition to TNFα, lymphotoxin α (LTα) binds to and activates TNFR1. Thus, TNFα and LTα together are known as TNF. To delineate the role of TNF signaling in glucose homeostasis, the present study ascertained how TNF signaling deficiency affects major regulatory components of glucose homeostasis. To this end, normal diet-fed male TNFR1 deficient mice (TNFR1-/-), TNFα/LTα/LTβ triple deficient mice (TNF/LT∆3), and their littermate controls were subjected to intraperitoneal glucose tolerance test, insulin tolerance test, and oral glucose tolerance test. The present results showed that TNFR1-/- and TNF/LT∆3 mice versus their controls had comparable body weight, tolerance to intraperitoneal glucose, and sensitivity to insulin. However, their tolerance to oral glucose was significantly increased. Additionally, glucose-induced insulin secretion assessments revealed that TNFR1 or TNF/LT deficiency significantly increased oral but not intraperitoneal glucose-induced insulin secretion. Consistently...Continue Reading
References
Jan 1, 1993·Science·G S HotamisligilB M Spiegelman
Dec 18, 1995·FEBS Letters·S Zhang, K H Kim
Sep 1, 1997·Diabetes·J VentreD E Moller
Jul 10, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P C TsiotraS A Raptis
Apr 16, 2005·European Journal of Immunology·Dmitry V KuprashSergei A Nedospasov
Aug 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hyeung-Jin JangJosephine M Egan
Mar 17, 2010·Biochimica Et Biophysica Acta·Katsumi TodaToshiji Saibara
Jan 3, 2012·Cytokine·Dass S Vinay, Byoung S Kwon
May 3, 2014·Reviews in Endocrine & Metabolic Disorders·Amandine Everard, Patrice D Cani
Apr 22, 2010·Journal of Diabetes Investigation·Yutaka SeinoDaisuke Yabe
Aug 21, 2014·Kidney International·Rafia S Al-Lamki, Tanya N Mayadas
Jun 29, 2015·Neuroscience·L Probert
Aug 14, 2015·Endocrinology·Jeffrey GagnonPatricia L Brubaker
Aug 16, 2015·Peptides·Berit Svendsen, Jens Juul Holst
Oct 17, 2015·Human Immunology·Ilaria Peluso, Maura Palmery
Feb 16, 2016·The Lancet. Diabetes & Endocrinology·Michael A Nauck, Juris J Meier
Aug 9, 2016·Cytokine·Chenxiao LiuMajian Hua
Nov 16, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Pål A OlsvikLiv Søfteland
Feb 10, 2017·Nature·Gökhan S Hotamisligil
Sep 18, 2017·Toxicology·Ziying HuZhekang Ying
Dec 10, 2017·The Lancet. Diabetes & Endocrinology·Simeon I Taylor
Mar 29, 2018·Science·Liping ZhaoChenhong Zhang
Apr 5, 2018·Cell Metabolism·Daniel J Drucker