TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model

Journal of Neuroimmunology
Heather A IoccaJenny P Y Ting

Abstract

Inflammatory cytokines have been implicated in the pathology of multiple neurologic diseases, including multiple sclerosis. We examined the role of the TNF family member TWEAK in neuroinflammation. Cuprizone-fed mice undergo neuroinflammation and demyelination in the brain, but upon removal of cuprizone from the diet, inflammation is resolved and remyelination occurs. Using this model, we demonstrate that mice lacking TWEAK exhibit a significant delay in demyelination and microglial infiltration. During remyelination, mice lacking the TWEAK gene demonstrate only a marginal delay in remyelination. Thus, this study identifies a primary role of TWEAK in promoting neuroinflammation and exacerbating demyelination during cuprizone-induced damage.

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Citations

Oct 24, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Juan J CarreroLuis M Blanco-Colio
Jul 23, 2013·Molecular Neurobiology·Arash NazeriAmit Bar-Or
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Jelle PraetPeter Ponsaerts
Nov 20, 2008·Journal of Neuropathology and Experimental Neurology·Barbara SerafiniFrancesca Aloisi
Jul 4, 2012·Journal of Autoimmunity·Ayan LahiriJacques-Olivier Pers
Mar 30, 2010·Neurobiology of Disease·Lorelei C TaylorGlenn K Matsushima
Nov 21, 2008·Journal of Neuroscience Research·Akvile NorkuteMarkus Kipp
Aug 21, 2013·British Journal of Pharmacology·Harald Wajant
Jan 8, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Klaus Thanke AspliJan Aaseth
Oct 6, 2009·Neuroscience·D K CrawfordS K Tiwari-Woodruff
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mukesh KumarAshok Kumar
Sep 26, 2020·Frontiers in Cellular Neuroscience·Melanie J PlastiniRoberta Brambilla
Aug 27, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xuefeng YinMary Simcox

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