TNFα up-regulates COX-2 in chronic progressive nephropathy through nuclear accumulation of RelB and NF-κB2

Archives of Physiology and Biochemistry
Junsi QiuRongquan Chen

Abstract

The pathogenesis of progressive nephropathies involves inflammatory factors. The inhibition of cyclooxygenase-2 (COX-2) can limit renal damage and inflammation. However, the mechanism of up-regulation of COX-2 in nephropathy is poorly defined. Here we found that tumor necrosis factor alpha (TNFα) was involved in expression of COX-2 in normal rat kidney (NRK) cell line. TNFα stimulated COX-2 production in a time-dependent manner in NRK cells by inducing nuclear accumulation of RelB and nuclear factor kappa B2 (NF-κB2) and their association with COX-2 gene promoter. Depletion of IκB-inducing kinase alpha, a positive regulator of activation of p100 processing to active p52, attenuated TNFα-induced COX-2 production. Furthermore, TNFα induced COX-2 production and nuclear import in anti-thymocyte serum (ATS) nephropathy. These data suggest that TNFα-RelB/p52 pathway may be involved in the early stages of renal damage, in part by stimulating COX-2 and inflammatory responses.

References

Jan 26, 1995·Nature·C W MüllerS C Harrison
Jan 12, 2000·Oncogene·C S WilliamsR N DuBois
Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J PlümpeC Trautwein
Dec 6, 2002·BMC Molecular Biology·Barbara KaltschmidtChristian Kaltschmidt
Oct 16, 2004·The Journal of Biological Chemistry·Guoliang QingGutian Xiao
Nov 26, 2004·British Journal of Clinical Pharmacology·Jan C BeckerThorsten Pohle
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Juan F Navarro-González, Carmen Mora-Fernández
Feb 13, 2008·Cell·Matthew S Hayden, Sankar Ghosh
Mar 24, 2009·Annual Review of Immunology·Sivakumar Vallabhapurapu, Michael Karin
Mar 27, 2010·International Journal of Cell Biology·Cyril SobolewskiMarc Diederich
Dec 22, 2010·Cell Research·Shao-Cong Sun
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Emanuela Ricciotti, Garret A FitzGerald
Oct 25, 2011·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Sayuri SuzukiMasatoshi Kitagawa
Jun 27, 2012·Molecular Endocrinology·Bingbing WangTodd Rosen
Aug 30, 2014·Cytokine & Growth Factor Reviews·Lisa M Sedger, Michael F McDermott

❮ Previous
Next ❯

Citations

Dec 7, 2018·Journal of Neuroinflammation·Vito Dozio, Jean-Charles Sanchez
Oct 18, 2020·Neuromolecular Medicine·Sally Shuxian KohWei-Yi Ong
Aug 16, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Marie-Christin SchulzGerald Schwerdt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.