TNFR1 mRNA expression level and TNFR1 gene polymorphisms are predictive markers for susceptibility to develop invasive pulmonary aspergillosis

International Journal of Immunopathology and Pharmacology
J SainzM Jurado

Abstract

Tumour necrosis factor (TNF) is primarily secreted by monocytes/macrophages and activated T lymphocytes in response to fungal infections. TNF acts through TNF receptor 1 (TNFR1) triggering a pro-inflammatory response, and therefore plays a pivotal role in immune regulation and host immune responses. We hypothesized that single nucleotide polymorphisms (SNPs) in TNFR1 gene may influence the innate immune response against Aspergillus. Three SNPs were genotyped in 275 individuals (144 immunocompromised haematological patients with high-risk of developing IPA and 131 healthy controls): TNFR1(-383(A/C)) (rs2234649) and TNFR1(-609(G/T)) (rs4149570) in the 5 prime UTR region, and TNFR1(+36(A/G)) SNP (rs767455) in the first exon of the gene. Of the 144 haematological patients, 77 patients developed Invasive Pulmonary Aspergillosis (IPA) infection and the remaining 67 patients were not infected. TNFR1(+36(A/G)) and TNFR1(-609(G/T)) were associated with IPA susceptibility (p=0.033 and p=0.018, respectively). A role of TNFR1 genetic variants in the susceptibility of patients to develop IPA was also supported by the significantly lower TNFR1 mRNA expression level in IPA than in IPA-resistant patients and the strong correlation between the ...Continue Reading

References

May 1, 1992·Immunology Today·L A Tartaglia, D V Goeddel
Dec 1, 1995·The Journal of Infectious Diseases·H NagaiV Kurup
Feb 1, 1997·Infection and Immunity·E CenciF Bistoni
Apr 1, 1997·Molecular Immunology·K M KroegerL J Abraham
May 23, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F OffnerB De Pauw
Oct 29, 2000·BMJ : British Medical Journal·D Kwiatkowski
Mar 13, 2001·Annual Review of Immunology·T TaniguchiN Tanaka
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
Jul 19, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·G R De La RosaD P Kontoyiannis
Dec 14, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Julian C Knight
Apr 22, 2005·The American Journal of Gastroenterology·Kevin A WaschkeGary E Wild
Dec 31, 2005·Nucleic Acids Research·V MatysE Wingender
Jan 18, 2006·Journal of Microbiological Methods·Kathrin LutherFrank Ebel
Apr 7, 2006·Molecular Immunology·Natalie DrorBen-Zion Levi
Feb 28, 2007·Genome Biology·Shobhit GuptaWilliam Stafford Noble
Oct 24, 2008·The New England Journal of Medicine·Pierre-Yves BochudMichael Boeckh

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Citations

Oct 23, 2012·Current Fungal Infection Reports·Michail S Lionakis
Aug 21, 2013·PLoS Pathogens·Cristina CunhaAgostinho Carvalho
Nov 19, 2014·Seminars in Immunopathology·Agnieszka Wójtowicz, Pierre-Yves Bochud
May 23, 2015·Frontiers in Microbiology·Ana Oliveira-CoelhoCristina Cunha
Aug 23, 2016·Current Clinical Microbiology Reports·Stacey A MaskarinecJohn R Perfect
Oct 12, 2011·Immunological Investigations·Cristina CunhaAgostinho Carvalho
May 7, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark S GresnigtFrank L van de Veerdonk
Mar 12, 2011·Nature Reviews. Immunology·Luigina Romani
Mar 29, 2014·BMC Infectious Diseases·Corine E DelsingMihai G Netea
Mar 19, 2020·Frontiers in Cellular and Infection Microbiology·Richard M Merkhofer, Bruce S Klein
Aug 30, 2020·Infectious Diseases and Therapy·Tananun TanpaibulePorpon Rotjanapan
Sep 20, 2011·Current Opinion in Infectious Diseases·Walter J F M van der VeldenJ Peter Donnelly
Jun 12, 2020·Current Fungal Infection Reports·Michail S Lionakis

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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