TNFRSF1B A1466G genotype is predictive of clinical efficacy after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.

Journal of Experimental & Clinical Cancer Research : CR
Akiko KuwaharaToshiyuki Sakaeda

Abstract

Currently definitive 5-fluorouracil (5-FU)/cisplatin (CDDP) -based chemotherapy is recognized as one of the most promising treatments for esophageal cancer. A series of studies performed found genetic polymorphisms and the plasma concentration of 5-FU to be predictive of acute severe toxicities and clinical response. Genetic polymorphisms of tumor necrosis factor (TNF) -alpha and its surface receptors, TNFRSF1A and TNFRSF1B have been examined in terms of susceptibility to various cancers. In this study, genetic polymorphisms of TNFRSF1B gene were evaluated Japanese esophageal squamous cell carcinoma (ESCC) patients treated with the definitive 5-FU/CDDP-based chemoradiotherapy and their predictive values of prognosis or severe acute toxicities were assessed. Forty-six patients with ESCC were treated with the definitive 5-FU/CDDP-based chemoradiotherapy, one course of which consisted of the continuous infusion of 5-FU for days 1-5 and 8-12, the infusion of CDDP on days 1 and 8, and the radiation at 2 Gy/day on days 1-5, 8-12, and 15-19, with a second course repeated after 2-week interval. Genetic polymorphisms of a TNF-alpha receptor TNFRSF1B gene were determined by a TaqMan(R) MGB probe-based polymerase chain reaction. The genot...Continue Reading

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Citations

May 21, 2011·International Journal of Radiation Oncology, Biology, Physics·Pei-Chun ChenEric Y Chuang
Jul 29, 2015·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A Ruffier-LoubièreG Calais
May 5, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Pallavi SinghalMausumi Bharadwaj
May 18, 2016·Pharmacogenomics·Enrica RumiatoDaniela Saggioro
Oct 18, 2011·European Journal of Gastroenterology & Hepatology·ShuTao ZhengXiaoMei Lu

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Methods Mentioned

BETA
genotyping
PCR
biopsy

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