TNFRSF1B in genetic predisposition to clinical neuropathy and effect on HDL cholesterol and glycosylated hemoglobin in type 2 diabetes

Diabetes Care
A V BenjafieldB J Morris

Abstract

Genetic variation in the tumor necrosis factor (TNF) receptor 2 gene (TNFRSF1B) has shown association with insulin resistance in type 2 diabetes, hypercholesterolemia, coronary artery disease, and essential hypertension. Here we tested the TNFRSF1B marker used in the latter studies in type 2 diabetes patients. A case-control study of a microsatellite marker with five alleles (CA13- CA17) in intron 4 of TNFRSF1B was performed in 357 well-characterized white patients and 183 healthy control subjects. The CA16 allele was associated with clinical neuropathy (frequency = 27% in 69 patients with the condition versus 16% in 230 subjects without the condition; chi2 = 9.0, P = 0.011; odds ratio = 2.1 [95% CI 1.2-3.8]). No association was seen with other complications or diabetes itself. The CA16 allele tracked with elevation plasma HDL cholesterol (1.3 +/- 0.2, 1.2 +/- 0.4, and 1.1 +/- 0.2 for CA16/CA16, CA16/-, and -/-, respectively; n = 9, 110, and 218, respectively; P = 0.009) and reduction in plasma glycosylated hemoglobin (6.6 +/- 0.3, 8.3 +/- 0.2, and 8.1 +/- 0.1 for CA16/CA16, CA16/-, and -/-, respectively; n = 9, 102, 205, respectively; P = 0.007) Significance remained after Bonferroni correction for multiple testing. Genetic va...Continue Reading

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Citations

Feb 14, 2006·Diabetes Technology & Therapeutics·Jose-Manuel Fernández-Real
Aug 19, 2011·BMC Medical Genetics·Rubina TabassumDwaipayan Bharadwaj
Oct 3, 2009·Journal of Diabetes and Its Complications·Juan YbarraJeroni Jurado
Jan 15, 2013·Journal of Biochemical and Molecular Toxicology·Kathryn A BaileyRebecca C Fry
Feb 1, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Eduardo EsteveJosé Manuel Fernández-Real
Sep 27, 2019·Annals of Clinical and Translational Neurology·Yating ZhaoXu Liu
Nov 25, 2004·Endocrine Reviews·Héctor F Escobar-MorrealeJosé L San Millán
Sep 10, 2003·Journal of Applied Physiology·Satu PajalaTaina Rantanen

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