TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function.

Stem Cell Research & Therapy
Ghada BeldiSina Naserian

Abstract

In addition to their multilineage potential, mesenchymal stem cells (MSCs) have a broad range of functions from tissue regeneration to immunomodulation. MSCs have the ability to modulate the immune response and change the progression of different inflammatory and autoimmune disorders. However, there are still many challenges to overcome before their widespread clinical administration including the mechanisms behind their immunoregulatory function. MSCs inhibit effector T cells and other immune cells, while inducing regulatory T cells (T regs), thus, reducing directly and indirectly the production of pro-inflammatory cytokines. TNF/TNFR signaling plays a dual role: while the interaction of TNFα with TNFR1 mediates pro-inflammatory effects and cell death, its interaction with TNFR2 mediates anti-inflammatory effects and cell survival. Many immunosuppressive cells like T regs, regulatory B cells (B regs), endothelial progenitor cells (EPCs), and myeloid-derived suppressor cells (MDSCs) express TNFR2, and this is directly related to their immunosuppression efficiency. In this article, we investigated the role of the TNFα/TNFR2 immune checkpoint signaling pathway in the immunomodulatory capacities of MSCs. Co-cultures of MSCs from w...Continue Reading

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Citations

Dec 22, 2020·Frontiers in Cell and Developmental Biology·Ghada BeldiSina Naserian
Dec 12, 2020·Stem Cell Research & Therapy·Sina NaserianGeorges Uzan
Mar 20, 2021·Journal of Tissue Engineering·Mahsa Nouri BarkestaniSara Shamdani
Apr 29, 2021·ImmunoTargets and Therapy·Yang YangXin Chen
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Dixin CuiMian Wan

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Methods Mentioned

BETA
magnetic-activated
PMA
flow cytometry
Fluorescence

Software Mentioned

FlowJo

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