TNNI3K in cardiovascular disease and prospects for therapy

Journal of Molecular and Cellular Cardiology
Annalisa MilanoConnie R Bezzina

Abstract

Cardiovascular diseases are an important cause of morbidity and mortality worldwide and the global burden of these diseases continues to grow. Therefore new therapies are urgently needed. The role of protein kinases in disease, including cardiac disease, is long recognized, making kinases important therapeutic targets. We here review the knowledge gathered in the last decade about troponin I-interacting kinase (TNNI3K), a kinase with cardiac-restricted expression that has been implicated in various cardiac phenotypes and diseases including heart failure, cardiomyopathy, ischemia/reperfusion injury and conduction of the cardiac electrical impulse.

References

Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J F MartinE N Olson
Nov 7, 1998·The Journal of Biological Chemistry·I PastuszakA D Elbein
Dec 11, 1999·Circulation Research·C BezzinaA A Wilde
Nov 1, 2002·The New England Journal of Medicine·Daniel LevyRamachandran S Vasan
Dec 10, 2002·Science·G ManningS Sudarsanam
May 21, 2004·Protein Science : a Publication of the Protein Society·Leila K MosaviZheng-Yu Peng
Mar 17, 2005·Cardiovascular Research·Joanne LaylandAjay M Shah
Apr 2, 2005·Nature Reviews. Genetics·Jonathan FlintRichard Mott
Aug 3, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Ferrin C WheelerDouglas A Marchuk
Jul 29, 2006·Nature Clinical Practice. Cardiovascular Medicine·Mark E AndersonHoward Schulman
Jan 22, 2008·Biochemistry. Biokhimii︠a︡·Yan FengXian-Min Meng
Jun 17, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Zhong-Fang LaiShokei Kim-Mitsuyama
Sep 19, 2009·PLoS Genetics·Ferrin C WheelerDouglas A Marchuk
Sep 22, 2010·Journal of Molecular and Cellular Cardiology·Brendon P SciclunaConnie R Bezzina
Oct 12, 2010·Nature Genetics·Elizabeth K SpeliotesRuth J F Loos
Jan 25, 2011·The Journal of Biological Chemistry·Derk Frank, Norbert Frey
Oct 27, 2011·Journal of Biomedicine & Biotechnology·Ralph KnöllMax Lab
Nov 1, 2011·Nature Biotechnology·Theonie AnastassiadisJeffrey R Peterson
Oct 23, 2012·Journal of Molecular and Cellular Cardiology·Hao TangDouglas A Marchuk
Jan 3, 2013·The Journal of Clinical Investigation·Derek J Hausenloy, Derek M Yellon
Nov 13, 2013·Nucleic Acids Research·Catherine M FarrellKim D Pruitt
Dec 10, 2013·Nucleic Acids Research·Paul FlicekStephen M J Searle

❮ Previous
Next ❯

Citations

Feb 20, 2020·Journal of Arrhythmia·Ranjit I Kylat, Ricardo A Samson
Mar 22, 2018·Journal of Medicinal Chemistry·Joanne PhilpLara S Kallander

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.