To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases

World Journal of Gastroenterology : WJG
Dipanjana Datta De, Susanta Roychoudhury

Abstract

Helicobacter pylori (H. pylori) have long been associated with a spectrum of disease outcomes in the gastro-duodenal system. Heterogeneity in bacterial virulence factors or strains is not enough to explain the divergent disease phenotypes manifested by the infection. This review focuses on host genetic factors that are involved during infection and eventually are thought to influence the disease phenotype. We have summarized the different host genes that have been investigated for association studies in H. pylori mediated duodenal ulcer or gastric cancer. We discuss that as the bacteria co-evolved with the host; these host gene also show much variation across different ethnic population. We illustrate the allelic distribution of interleukin-1B, across different population which is one of the most popular candidate gene studied with respect to H. pylori infections. Further, we highlight that several polymorphisms in the pathway gene can by itself or collectively affect the acid secretion pathway axis (gastrin: somatostatin) thereby resulting in a spectrum of disease phenotype.

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Citations

Mar 22, 2016·The Journal of Trauma and Acute Care Surgery·Kjetil Søreide
Aug 10, 2016·Frontiers in Microbiology·Mydhily R B NairSantanu Chattopadhyay
Aug 25, 2018·Expert Review of Clinical Pharmacology·Guillermo García-RayadoAngel Lanas
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Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenji ZhangShili Sun

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